Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1232246..1232874 Replicon chromosome
Accession NZ_CP020414
Organism Leptospira interrogans serovar Copenhageni strain FDAARGOS_203

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag A6J42_RS07090 Protein ID WP_000281042.1
Coordinates 1232476..1232874 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q72P17
Locus tag A6J42_RS07085 Protein ID WP_001192484.1
Coordinates 1232246..1232476 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J42_RS07055 1227847..1228056 - 210 WP_000041838.1 hypothetical protein -
A6J42_RS07060 1228188..1228817 + 630 WP_001081629.1 helix-turn-helix domain-containing protein -
A6J42_RS07065 1229024..1229947 + 924 WP_000680714.1 M28 family peptidase -
A6J42_RS07070 1230206..1230895 + 690 WP_000590460.1 SH3 domain-containing protein -
A6J42_RS07075 1231098..1231427 + 330 WP_000611884.1 hypothetical protein -
A6J42_RS07080 1231424..1231954 + 531 WP_000129981.1 hypothetical protein -
A6J42_RS07085 1232246..1232476 + 231 WP_001192484.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A6J42_RS07090 1232476..1232874 + 399 WP_000281042.1 type II toxin-antitoxin system VapC family toxin Toxin
A6J42_RS07095 1232972..1233274 + 303 WP_000479559.1 hypothetical protein -
A6J42_RS07100 1233329..1234476 + 1148 WP_100225665.1 IS3-like element IS1500A family transposase -
A6J42_RS07105 1234531..1234758 + 228 WP_000130601.1 hypothetical protein -
A6J42_RS07110 1234901..1235977 + 1077 WP_001170562.1 hypothetical protein -
A6J42_RS07115 1235978..1236436 + 459 WP_001239008.1 GNAT family N-acetyltransferase -
A6J42_RS07120 1236653..1237513 - 861 WP_000682236.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T74659 WP_000281042.1 NZ_CP020414:1232476-1232874 [Leptospira interrogans serovar Copenhageni]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

>T74659 NZ_CP020414:1232476-1232874 [Leptospira interrogans serovar Copenhageni]
ATGTATCTTTTGGATACCAATATTTGTATTTTTCTAATTAAAAAGAAAAATGCGACTCTGTTAGAAAATCTTAAGAAAAA
ATTAAATAAAGATCTATTTGTTTCGTCTTTAACTGTTGCGGAACTTGAGTTTGGAATTCAGAAAAGCGAATTTAAAGAAA
AGAATAAAGTTGCACTAATCGAATTTTTAACGATTTTCAATATACTTTCCTTTTCTGATAAAGATGCAGAGTCTTACGGT
ATCATCAGAGCGGATTTGGAGAGGAAAGGTAATGTAATCGGTTCAATAGACATGTTACTTGCCGCTCAAGCAATTGCTAA
TAATTATATCTTTGTTACTAATAATACAAAAGAATTTAAAAGAATTAAGGCTTTAAAAATAGAAAATTGGACACAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8698.99 Da        Isoelectric Point: 9.8940

>AT74659 WP_001192484.1 NZ_CP020414:1232246-1232476 [Leptospira interrogans serovar Copenhageni]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEGREQPKSDKREKL

Download         Length: 231 bp

>AT74659 NZ_CP020414:1232246-1232476 [Leptospira interrogans serovar Copenhageni]
ATGCAAACAGCCAAATTATTTATAAATGGAAGAAGTCAAGCGGTCAGATTACCAAAAGAATTTCAATTTACCGGAGATGA
TGTTCTTATCCAAAAAGTTGGAGAGGCGGTAATATTGGTTCCGAAAAACAAGGCCTGGAACGTATTTTTAGAAGGATTGA
ACGGGTTTTCAGATGATTTCTTTAAGGAGGGGAGAGAACAACCGAAATCTGATAAAAGAGAAAAACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6HAN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2D7U1

References