Detailed information of TA system TA074657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 1615575..1616050
• Replicon: chromosome
• Accession: NZ_CP020411
• Organism: Haemophilus influenzae strain FDAARGOS_199

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: -
• Locus tag: A6J38_RS07985
• Protein ID: WP_005693712.1
• Coordinates: 1615775..1616050 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: A0A0M1GIA6
• Locus tag: A6J38_RS07980
• Protein ID: WP_005649350.1
• Coordinates: 1615575..1615766 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J38_RS07955	1611154..1611786	+	633	WP_032828392.1	dTMP kinase	-
A6J38_RS07960	1611783..1612766	+	984	WP_010868989.1	DNA polymerase III subunit delta'	-
A6J38_RS07965	1612821..1613603	+	783	WP_005693710.1	YchF/TatD family DNA exonuclease	-
A6J38_RS07970	1613630..1614154	+	525	WP_005652096.1	DUF1523 family protein	-
A6J38_RS07975	1614205..1615503	+	1299	WP_005693711.1	hemolysin family protein	-
A6J38_RS07980	1615575..1615766	+	192	WP_005649350.1	DUF5397 domain-containing protein	Antitoxin
A6J38_RS07985	1615775..1616050	+	276	WP_005693712.1	endoribonuclease VapD	Toxin
A6J38_RS07990	1616143..1616673	+	531	WP_005686915.1	hypothetical protein	-
A6J38_RS07995	1616745..1618244	+	1500	WP_005693713.1	fused PTS fructose transporter subunit IIA/HPr protein	-
A6J38_RS08000	1618246..1619187	+	942	WP_005693714.1	1-phosphofructokinase	-
A6J38_RS08005	1619189..1620859	+	1671	WP_005693715.1	fructose-specific PTS transporter subunit EIIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (6-85)

Antitoxin

• Protein of unknown function DUF5397 (1-63)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10543.06 Da
• Isoelectric Point: 7.0053

>T74657 WP_005693712.1 NZ_CP020411:1615775-1616050 [Haemophilus influenzae]
MYAIAFLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYINMNEDMANLFQAMNALKQLAWISQSVRDIRAFRIE
QWSDFTDFIRN

Nucleotide

• Length: 276 bp

>T74657 NZ_CP020411:1615775-1616050 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGACAT
TGGCGCAGTCTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATATCAACATGAATGAAGATATGGCGAATC
TCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATTGAG
CAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7047.02 Da
• Isoelectric Point: 3.9930

>AT74657 WP_005649350.1 NZ_CP020411:1615575-1615766 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Nucleotide

• Length: 192 bp

>AT74657 NZ_CP020411:1615575-1615766 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0M1GIA6