Detailed information of TA system TA074656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1385754..1386402
• Replicon: chromosome
• Accession: NZ_CP020411
• Organism: Haemophilus influenzae strain FDAARGOS_199

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: A6J38_RS06795
• Protein ID: WP_005694481.1
• Coordinates: 1385754..1386113 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: A6J38_RS06800
• Protein ID: WP_005650837.1
• Coordinates: 1386106..1386402 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J38_RS06780	1382017..1382181	-	165	WP_005694626.1	hypothetical protein	-
A6J38_RS06790	1382503..1385484	+	2982	WP_105163172.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
A6J38_RS06795	1385754..1386113	+	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6J38_RS06800	1386106..1386402	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
A6J38_RS06805	1386563..1388479	+	1917	WP_005694483.1	ABC transporter ATP-binding protein	-
A6J38_RS06810	1388489..1389025	+	537	WP_005694485.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
A6J38_RS06815	1389041..1389592	+	552	WP_005694486.1	threonylcarbamoyl-AMP synthase	-
A6J38_RS06820	1389596..1390414	+	819	WP_005694487.1	shikimate dehydrogenase	-
A6J38_RS06825	1390411..1390968	+	558	WP_005694489.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T74656 WP_005694481.1 NZ_CP020411:1385754-1386113 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T74656 NZ_CP020411:1385754-1386113 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAAAGTTATTAAGCGAACTCGGGACGTCTGTTGGCA
AACCCTATGTGAAACATTTAGACGGTGAAATTTGGGAACTTCGTCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATG
GATGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACAGCCCAACA
ACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT74656 WP_005650837.1 NZ_CP020411:1386106-1386402 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT74656 NZ_CP020411:1386106-1386402 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTTCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0