Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1080313..1080944 Replicon chromosome
Accession NZ_CP020411
Organism Haemophilus influenzae strain FDAARGOS_199

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag A6J38_RS05280 Protein ID WP_005651560.1
Coordinates 1080546..1080944 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag A6J38_RS05275 Protein ID WP_005648011.1
Coordinates 1080313..1080546 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J38_RS05250 1075791..1076993 - 1203 WP_005693302.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
A6J38_RS05255 1077157..1077822 + 666 WP_013527272.1 DNA repair protein RadC -
A6J38_RS05260 1078036..1078272 + 237 WP_005542826.1 50S ribosomal protein L28 -
A6J38_RS05265 1078284..1078454 + 171 WP_005613503.1 50S ribosomal protein L33 -
A6J38_RS05270 1078802..1080166 + 1365 WP_005693298.1 diaminobutyrate--2-oxoglutarate transaminase -
A6J38_RS05275 1080313..1080546 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
A6J38_RS05280 1080546..1080944 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
A6J38_RS05285 1080964..1082499 + 1536 WP_005693296.1 L-2,4-diaminobutyrate decarboxylase -
A6J38_RS05290 1082732..1083547 + 816 WP_005693293.1 DNA-formamidopyrimidine glycosylase -
A6J38_RS05295 1083621..1084643 - 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
A6J38_RS05300 1084644..1085762 - 1119 WP_005693291.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T74653 WP_005651560.1 NZ_CP020411:1080546-1080944 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T74653 NZ_CP020411:1080546-1080944 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT74653 WP_005648011.1 NZ_CP020411:1080313-1080546 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT74653 NZ_CP020411:1080313-1080546 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References