Detailed information of TA system TA074646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3098811..3099801
• Replicon: chromosome
• Accession: NZ_CP020409
• Organism: Yersinia sp. FDAARGOS_228

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9M4G2
• Locus tag: A6J67_RS14330
• Protein ID: WP_005184404.1
• Coordinates: 3098811..3099269 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9M4Z0
• Locus tag: A6J67_RS14335
• Protein ID: WP_005184401.1
• Coordinates: 3099355..3099801 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J67_RS14300	3094591..3095256	+	666	WP_005184417.1	phage shock protein PspA	-
A6J67_RS14305	3095400..3095627	+	228	WP_032906081.1	envelope stress response membrane protein PspB	-
A6J67_RS14310	3095627..3096001	+	375	WP_005184415.1	envelope stress response membrane protein PspC	-
A6J67_RS14315	3096110..3096349	+	240	WP_050073360.1	phage shock protein PspD	-
A6J67_RS14320	3096330..3097727	+	1398	WP_032906079.1	YcjX family protein	-
A6J67_RS14325	3097724..3098785	+	1062	WP_050296992.1	YcjF family protein	-
A6J67_RS14330	3098811..3099269	-	459	WP_005184404.1	RES family NAD+ phosphorylase	Toxin
A6J67_RS14335	3099355..3099801	-	447	WP_005184401.1	DUF2384 domain-containing protein	Antitoxin
A6J67_RS14340	3100119..3101696	+	1578	WP_042569805.1	transcriptional regulator TyrR	-
A6J67_RS14345	3101809..3102312	-	504	WP_005184397.1	thiol peroxidase	-
A6J67_RS14350	3102466..3103437	+	972	WP_042569804.1	L-Ala-D/L-Glu epimerase	-
A6J67_RS14355	3103434..3104141	-	708	WP_032906074.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17201.65 Da
• Isoelectric Point: 4.8938

>T74646 WP_005184404.1 NZ_CP020409:c3099269-3098811 [Yersinia sp. FDAARGOS_228]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALSFAFDPRLK

Nucleotide

• Length: 459 bp

>T74646 NZ_CP020409:c3099269-3098811 [Yersinia sp. FDAARGOS_228]
ATGATGCTTTATCGCATCGTGATGCGCCGCTACCTGGCTTCAACCTGGACCGGTTATGGCGCTGAAATCTATGGTGGGCG
CTGGAATCATAAAGGCCACGCCGCCATCTATTTAGCCAGTAGTGTGTCACTGGCGATGCTGGAAACACTGGTACATATTC
AAGACAGCTCAACACTCAGCGAGTTTGAGTTATTCCAGATTGAGATTGATGACAGCAATATCATGCTGTTACAACCACAG
GATTGGCCACTGGACTGGCGCAATGACCCCGCGCCTGCGGCTACGATGGATATCGGCACAGAATGGCTGGAATCAGAATC
ATCAATTGGATTGCTGGTCCCATCCACACTGGTGCCTTCAGAACATAATATGCTGGTCAATCCGCGCCACAAAGATTTTC
AGGCCTGCTTGAGTACCGCCAAAGCACTCTCCTTTGCCTTCGATCCCCGATTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16256.70 Da
• Isoelectric Point: 9.1234

>AT74646 WP_005184401.1 NZ_CP020409:c3099801-3099355 [Yersinia sp. FDAARGOS_228]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT74646 NZ_CP020409:c3099801-3099355 [Yersinia sp. FDAARGOS_228]
ATGAGAGCTTATCAACCTACCCCCACAACGAAAGCAGGGGCACTCTGGCGAGAAATTGGTTTGCCAGCCAGCCGTGGCAC
GGTATTAGTCGACAGCATCAAGCTGGGTTTTTCTGTCGATGTCATCGACAGTATCCATCTTTGGGCCTCTATGCCTAAAT
CTGAAATATTGCGCGCTACCGGTATTCCCAGCCGTAGCCTGACCCGCCGACGTACCCATGATGGCCGTTTTACACCAGAA
GAGAGTGAGCGAATCGCGCGCTTCGTGCGGGTAATGGATGCCGCAGTTGACCTCTTCGGTGGTGATAAAGGCAAAGCTAT
CGTCTGGATGTCGACACCCATTAAGGGGCTTGGGCACCGCAGTCCTGACTCACTGCTGGAGACCGAAACCGGCGCGTTAG
AAATCTGCGATTTAATTGGGCGGCTGGAACACGGTGTATTTTCATAG

Structures

Toxin

• AlphaFold DB: A0A0T9M4G2

Antitoxin

• AlphaFold DB: A0A0T9M4Z0