Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2114183..2114718 Replicon chromosome
Accession NZ_CP020409
Organism Yersinia sp. FDAARGOS_228

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9M850
Locus tag A6J67_RS09690 Protein ID WP_042568392.1
Coordinates 2114431..2114718 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9M846
Locus tag A6J67_RS09685 Protein ID WP_032905973.1
Coordinates 2114183..2114434 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J67_RS09660 2109610..2110113 + 504 WP_042568395.1 ferredoxin-type protein NapF -
A6J67_RS09665 2110103..2110369 + 267 WP_032905977.1 chaperone NapD -
A6J67_RS09670 2110366..2112861 + 2496 WP_032905975.1 nitrate reductase catalytic subunit NapA -
A6J67_RS09675 2112957..2113424 + 468 WP_042568394.1 nitrate reductase cytochrome c-type subunit -
A6J67_RS09680 2113453..2114052 + 600 WP_042568393.1 cytochrome c-type protein NapC -
A6J67_RS09685 2114183..2114434 + 252 WP_032905973.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A6J67_RS09690 2114431..2114718 + 288 WP_042568392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6J67_RS09695 2114748..2115323 + 576 WP_042570012.1 GDP-mannose pyrophosphatase NudK -
A6J67_RS09700 2115659..2117938 + 2280 WP_005183822.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
A6J67_RS09705 2118025..2118480 - 456 WP_032905970.1 YaiI/YqxD family protein -
A6J67_RS09710 2118480..2119406 - 927 WP_005183819.1 oxygen-dependent coproporphyrinogen oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.03 Da        Isoelectric Point: 10.3510

>T74637 WP_042568392.1 NZ_CP020409:2114431-2114718 [Yersinia sp. FDAARGOS_228]
MTYAVKFREEALKEWHKLDKTIQQQFAKKLKKCSDNPHIESAKLRGMKNCYKIKLRSSGFRLVYEVIDDVLIVAVVAVGK
RDRSEVYNLASDRLR

Download         Length: 288 bp

>T74637 NZ_CP020409:2114431-2114718 [Yersinia sp. FDAARGOS_228]
ATGACCTATGCCGTTAAGTTCAGAGAAGAAGCGCTAAAGGAATGGCACAAACTGGATAAGACGATACAACAGCAATTTGC
CAAGAAATTAAAAAAGTGCAGCGATAATCCGCATATTGAAAGCGCTAAACTACGTGGTATGAAAAACTGCTACAAAATTA
AATTACGATCCTCTGGATTTCGATTAGTGTATGAAGTTATCGATGATGTGTTGATCGTTGCTGTGGTTGCAGTAGGAAAA
AGAGATCGTAGCGAGGTGTATAACCTTGCAAGTGACCGATTACGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9255.56 Da        Isoelectric Point: 4.3287

>AT74637 WP_032905973.1 NZ_CP020409:2114183-2114434 [Yersinia sp. FDAARGOS_228]
MPSIILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPAFYCVPAELYEQIMEALDDHELAELVNRRRHQPLLDIDLD
SYL

Download         Length: 252 bp

>AT74637 NZ_CP020409:2114183-2114434 [Yersinia sp. FDAARGOS_228]
ATGCCAAGTATAATTTTGACTGATACCAGTGCCAGCGTGAGCGAACTGAAAAAAAATCCAATGGCAACAGTGAACGCTGG
GGCCGGTTTCCCCGTAGCTATCCTGAACCGCAATCAACCCGCATTCTATTGTGTACCCGCAGAACTATATGAACAAATAA
TGGAAGCGCTTGATGATCACGAATTAGCTGAGTTGGTTAACAGGCGGCGCCATCAACCCTTGCTTGATATCGATTTGGAT
AGCTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M850

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M846

References