Detailed information of TA system TA074636

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1340787..1341492
• Replicon: chromosome
• Accession: NZ_CP020409
• Organism: Yersinia sp. FDAARGOS_228

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: A6J67_RS06150
• Protein ID: WP_080608089.1
• Coordinates: 1340787..1341158 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: A6J67_RS06155
• Protein ID: WP_080608090.1
• Coordinates: 1341160..1341492 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J67_RS06110	1336032..1336523	+	492	WP_192945362.1	hypothetical protein	-
A6J67_RS06115	1336663..1336929	+	267	WP_080608082.1	hypothetical protein	-
A6J67_RS06120	1337428..1338249	+	822	WP_080608083.1	DUF945 domain-containing protein	-
A6J67_RS06125	1338249..1338512	+	264	WP_080608084.1	hypothetical protein	-
A6J67_RS06130	1338641..1339072	+	432	WP_080608085.1	antirestriction protein	-
A6J67_RS06135	1339092..1339577	+	486	WP_080608086.1	DNA repair protein RadC	-
A6J67_RS06140	1339603..1340391	+	789	WP_080608087.1	hypothetical protein	-
A6J67_RS06145	1340405..1340731	+	327	WP_080608088.1	hypothetical protein	-
A6J67_RS06150	1340787..1341158	+	372	WP_080608089.1	TA system toxin CbtA family protein	Toxin
A6J67_RS06155	1341160..1341492	+	333	WP_080608090.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
A6J67_RS06160	1341577..1342437	+	861	WP_080608091.1	DUF4942 domain-containing protein	-
A6J67_RS06165	1342734..1343294	+	561	WP_050536341.1	hypothetical protein	-
A6J67_RS06170	1343611..1344468	-	858	WP_080608092.1	hypothetical protein	-
A6J67_RS06175	1344461..1346011	-	1551	WP_080608093.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (14-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13707.75 Da
• Isoelectric Point: 8.4254

>T74636 WP_080608089.1 NZ_CP020409:1340787-1341158 [Yersinia sp. FDAARGOS_228]
MKPRPTPPGALTVPVIYQQLLAFLLEHYYGLSLNDTPYHDEQVIAQQIEREISVGDTVNALVEKYALVRIGRAGFSALAQ
DTTLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIQPQRKI

Nucleotide

• Length: 372 bp

>T74636 NZ_CP020409:1340787-1341158 [Yersinia sp. FDAARGOS_228]
ATGAAACCACGTCCCACCCCACCGGGCGCATTGACCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTCCTGCTGGAGCA
TTACTACGGCCTGAGCCTCAACGATACGCCTTATCACGATGAACAGGTGATTGCGCAACAGATTGAGCGGGAGATTTCAG
TGGGTGATACCGTCAATGCTCTGGTTGAAAAATATGCTCTGGTGCGTATCGGCCGTGCCGGGTTCAGTGCATTGGCGCAA
GACACCACGCTGAGCAAGGGAGATATCGCCCGAGCACGCCAGGCTGCGGGGCTGTGGCGAGCACATTTTCCGCCCACCTT
GCTCTACCCAACCGAGTCCCTCAACCCTATTCAACCACAGAGAAAAATTTAG

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12030.63 Da
• Isoelectric Point: 6.3159

>AT74636 WP_080608090.1 NZ_CP020409:1341160-1341492 [Yersinia sp. FDAARGOS_228]
MDNNITTAPAWGLQCDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGEWVCDADTLGSHGYVYISVYQKLA

Nucleotide

• Length: 333 bp

>AT74636 NZ_CP020409:1341160-1341492 [Yersinia sp. FDAARGOS_228]
ATGGATAACAACATTACCACCGCCCCGGCATGGGGCCTGCAATGTGATATTACACCACGGTTGGGAGCCCGATTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAACTGCTGTCCGGTGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAATGGGTCTGTGACGCGGATACGCTGGGCAGTCACGGTTATGTCTATATCTCGGTATATCA
GAAACTGGCTTGA