Detailed information of TA system TA074633

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 12860..13326
• Replicon: chromosome
• Accession: NZ_CP020409
• Organism: Yersinia sp. FDAARGOS_228

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A6J67_RS00075
• Protein ID: WP_050088509.1
• Coordinates: 13051..13326 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A6J67_RS00070
• Protein ID: WP_050288746.1
• Coordinates: 12860..13051 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6J67_RS00055	8090..9247	+	1158	WP_005188243.1	alcohol dehydrogenase	-
A6J67_RS00060	9564..10397	+	834	WP_080607975.1	2,5-didehydrogluconate reductase DkgA	-
A6J67_RS00065	10419..12689	-	2271	WP_005188248.1	YgiQ family radical SAM protein	-
A6J67_RS00070	12860..13051	+	192	WP_050288746.1	hypothetical protein	Antitoxin
A6J67_RS00075	13051..13326	+	276	WP_050088509.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
A6J67_RS00080	13473..14900	-	1428	WP_005188253.1	cell division protein FtsP	-
A6J67_RS00085	15072..15812	-	741	WP_050073901.1	1-acylglycerol-3-phosphate O-acyltransferase	-
A6J67_RS00090	16035..18302	-	2268	WP_042569053.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10460.94 Da
• Isoelectric Point: 4.7385

>T74633 WP_050088509.1 NZ_CP020409:13051-13326 [Yersinia sp. FDAARGOS_228]
MLPIKWTDEAKTDLYALIAFITEENPYAAESLLHQLEDSVLPATEHPYMFRSGRVPGTREMVAHPNYVIIYQVMADQISV
LNVVHSRQEYP

Nucleotide

• Length: 276 bp

>T74633 NZ_CP020409:13051-13326 [Yersinia sp. FDAARGOS_228]
ATGCTCCCTATAAAATGGACTGACGAAGCAAAGACGGATCTTTATGCACTAATCGCGTTCATCACAGAAGAAAACCCTTA
CGCAGCAGAATCACTACTTCACCAACTGGAAGACTCCGTTCTTCCTGCTACTGAGCATCCCTATATGTTTCGCTCAGGTA
GAGTTCCTGGCACTCGAGAAATGGTGGCGCATCCCAATTACGTTATTATTTATCAGGTGATGGCTGACCAAATCAGCGTG
TTAAACGTTGTTCACTCTCGACAGGAATACCCGTAG

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7176.21 Da
• Isoelectric Point: 7.0117

>AT74633 WP_050288746.1 NZ_CP020409:12860-13051 [Yersinia sp. FDAARGOS_228]
MSTKLSPIVSEFETEEQAESYDLWFRAKVEASMNSPKPQIPHDEVMAGARKIIEQAKARRKLA

Nucleotide

• Length: 192 bp

>AT74633 NZ_CP020409:12860-13051 [Yersinia sp. FDAARGOS_228]
ATGAGCACTAAATTATCACCAATCGTCTCTGAATTTGAAACCGAAGAACAGGCGGAAAGCTACGATCTTTGGTTCCGGGC
TAAGGTCGAGGCATCAATGAATAGCCCCAAACCCCAAATTCCTCACGATGAAGTCATGGCGGGTGCGCGCAAAATTATTG
AACAAGCCAAAGCACGGAGGAAGCTGGCTTAA