Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 806134..806943 Replicon chromosome
Accession NZ_CP020406
Organism Staphylococcus lugdunensis strain FDAARGOS_222

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag A6J61_RS03905 Protein ID WP_002458758.1
Coordinates 806773..806943 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag A6J61_RS03900 Protein ID WP_070648686.1
Coordinates 806134..806733 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J61_RS03880 801722..803179 + 1458 WP_002477974.1 ABC transporter substrate-binding protein/permease -
A6J61_RS03885 803172..803896 + 725 Protein_723 amino acid ABC transporter ATP-binding protein -
A6J61_RS03890 804354..805496 + 1143 WP_103284502.1 tRNA epoxyqueuosine(34) reductase QueG -
A6J61_RS03895 805498..805968 + 471 WP_002458756.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
A6J61_RS03900 806134..806733 + 600 WP_070648686.1 glucosamine-6-phosphate isomerase Antitoxin
A6J61_RS03905 806773..806943 + 171 WP_002458758.1 hypothetical protein Toxin
A6J61_RS03910 807117..807512 + 396 WP_002458759.1 hypothetical protein -
A6J61_RS03915 807640..809025 + 1386 WP_070648688.1 class II fumarate hydratase -
A6J61_RS03920 809090..809926 - 837 WP_002477978.1 RluA family pseudouridine synthase -
A6J61_RS03925 810094..811206 + 1113 WP_060795476.1 GAF domain-containing sensor histidine kinase -
A6J61_RS03930 811228..811851 + 624 WP_002477980.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6565.10 Da        Isoelectric Point: 4.6723

>T74613 WP_002458758.1 NZ_CP020406:806773-806943 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Download         Length: 171 bp

>T74613 NZ_CP020406:806773-806943 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22637.55 Da        Isoelectric Point: 4.9539

>AT74613 WP_070648686.1 NZ_CP020406:806134-806733 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLMLQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Download         Length: 600 bp

>AT74613 NZ_CP020406:806134-806733 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATGTTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References