74612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 666472..666989 Replicon chromosome
Accession NZ_CP020406
Organism Staphylococcus lugdunensis strain FDAARGOS_222

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag A6J61_RS03115 Protein ID WP_002461192.1
Coordinates 666639..666989 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag A6J61_RS03110 Protein ID WP_002461193.1
Coordinates 666472..666642 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J61_RS03085 662297..662779 + 483 WP_002492078.1 PH domain-containing protein -
A6J61_RS03090 662772..664286 + 1515 WP_080606540.1 PH domain-containing protein -
A6J61_RS03095 664273..664785 + 513 WP_002478976.1 PH domain-containing protein -
A6J61_RS03100 664797..665189 + 393 WP_002461196.1 holo-ACP synthase -
A6J61_RS03105 665237..666385 + 1149 WP_070647975.1 alanine racemase -
A6J61_RS03110 666472..666642 + 171 WP_002461193.1 hypothetical protein Antitoxin
A6J61_RS03115 666639..666989 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
A6J61_RS03120 667423..668424 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
A6J61_RS03125 668515..668841 + 327 WP_002461190.1 anti-sigma factor antagonist -
A6J61_RS03130 668843..669322 + 480 WP_012990787.1 anti-sigma B factor RsbW -
A6J61_RS03135 669297..670067 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T74612 WP_002461192.1 NZ_CP020406:666639-666989 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T74612 NZ_CP020406:666639-666989 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT74612 WP_002461193.1 NZ_CP020406:666472-666642 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT74612 NZ_CP020406:666472-666642 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References