Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2075600..2076245 Replicon chromosome
Accession NZ_CP020405
Organism Pasteurella multocida strain FDAARGOS_218

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A6J57_RS09775 Protein ID WP_016533497.1
Coordinates 2076063..2076245 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8E2AAC1
Locus tag A6J57_RS09770 Protein ID WP_005756614.1
Coordinates 2075600..2076034 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J57_RS09730 2071186..2071761 + 576 WP_005756625.1 hypothetical protein -
A6J57_RS09735 2072237..2072854 + 618 WP_032854013.1 KilA-N domain-containing protein -
A6J57_RS09740 2073122..2073457 + 336 WP_005756621.1 hypothetical protein -
A6J57_RS09745 2073468..2074019 + 552 WP_005756619.1 hypothetical protein -
A6J57_RS09750 2074134..2074499 + 366 WP_032854011.1 phage holin, lambda family -
A6J57_RS09755 2074471..2075055 + 585 WP_005756617.1 glycoside hydrolase family 19 protein -
A6J57_RS09760 2075058..2075381 + 324 WP_005756616.1 DUF2570 family protein -
A6J57_RS09770 2075600..2076034 - 435 WP_005756614.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A6J57_RS09775 2076063..2076245 - 183 WP_016533497.1 type II toxin-antitoxin system HicA family toxin Toxin
A6J57_RS09780 2076328..2076864 + 537 WP_005756612.1 terminase small subunit -
A6J57_RS09785 2076848..2078080 + 1233 WP_005756610.1 PBSX family phage terminase large subunit -
A6J57_RS09790 2078090..2079493 + 1404 WP_005756608.1 DUF4055 domain-containing protein -
A6J57_RS09795 2079483..2081084 + 1602 WP_005756605.1 minor capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2046416..2107384 60968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-134)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6605.77 Da        Isoelectric Point: 10.4152

>T74610 WP_016533497.1 NZ_CP020405:c2076245-2076063 [Pasteurella multocida]
VNSHDLIKELTAIGCTELRCKGSHHIWYSPKTGKTFPVPHPKKDLPIGTVRSIKKSAGLL

Download         Length: 183 bp

>T74610 NZ_CP020405:c2076245-2076063 [Pasteurella multocida]
GTGAACTCACACGACTTAATCAAGGAACTGACAGCAATTGGCTGTACTGAATTGAGATGTAAAGGGTCGCACCATATATG
GTATTCACCTAAAACAGGAAAGACGTTTCCTGTTCCGCATCCCAAGAAAGATTTACCAATAGGTACCGTCAGATCCATAA
AGAAATCGGCAGGGCTTTTATAG

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16603.84 Da        Isoelectric Point: 4.2518

>AT74610 WP_005756614.1 NZ_CP020405:c2076034-2075600 [Pasteurella multocida]
MLFTIGVETPKNENEAFGLCVPALFNETYSCFSAADTVEEIIPTVTDAIYTILEIMVEDNFDISQIKDLGFMHYKQQKDF
EFCDSWLLIDVDITAYFGKRQRVNVVLPQYLIDRIDQRVANNPTYKDRSHFLTIASQRELSSSL

Download         Length: 435 bp

>AT74610 NZ_CP020405:c2076034-2075600 [Pasteurella multocida]
ATGTTATTTACTATTGGTGTTGAAACGCCAAAAAATGAAAATGAAGCGTTTGGCTTATGTGTGCCTGCTCTTTTTAATGA
AACATATTCTTGTTTTAGTGCAGCTGATACAGTTGAAGAAATTATTCCAACAGTGACTGATGCTATCTATACAATTTTGG
AGATAATGGTCGAAGATAACTTCGACATTTCACAAATAAAAGATTTGGGTTTCATGCATTACAAACAACAAAAGGATTTT
GAATTTTGCGATAGCTGGTTGTTAATTGATGTTGATATCACAGCTTATTTCGGTAAGCGTCAACGTGTGAATGTTGTGCT
ACCACAATATTTAATTGACAGAATAGATCAGCGTGTAGCAAATAACCCAACTTACAAAGATCGCAGCCATTTCTTAACTA
TTGCTTCACAACGAGAGCTATCATCATCTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References