Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2243922..2244542 Replicon chromosome
Accession NZ_CP020398
Organism Burkholderia multivorans strain FDAARGOS_246

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag A8H40_RS27150 Protein ID WP_012217495.1
Coordinates 2243922..2244239 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag A8H40_RS27155 Protein ID WP_006398012.1
Coordinates 2244243..2244542 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H40_RS27135 2240457..2241890 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
A8H40_RS27140 2241919..2243559 - 1641 WP_006398015.1 acetolactate synthase large subunit -
A8H40_RS27150 2243922..2244239 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H40_RS27155 2244243..2244542 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
A8H40_RS27160 2244575..2245861 - 1287 WP_035487943.1 DUF445 domain-containing protein -
A8H40_RS27165 2245976..2247196 - 1221 WP_006411378.1 FAD-dependent oxidoreductase -
A8H40_RS27170 2247186..2247512 - 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
A8H40_RS27175 2247530..2248018 - 489 WP_006398008.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
A8H40_RS27180 2248033..2249304 - 1272 WP_006411366.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T74605 WP_012217495.1 NZ_CP020398:2243922-2244239 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T74605 NZ_CP020398:2243922-2244239 [Burkholderia multivorans]
ATGCCTTACCTTGCTCCAACGTTCAGCATCCGGACGACCGCCGTGTTCGACGCGTGGTTTGCCGGCCTGCAGGACCGCAC
CGCGAAGCGCCGCATTCAGGCGCGCATCGATCGGCTGTCGATGGGCAATCTGGGCAACTGGAAGTCCGTCGGGTCGCCCG
TCTACGAGATGCGCATCGATCACGGCCCCGGCTATCGCGTGTACTTCGTGCGGCGGCGCACGATATGGGTCGTCCTGCTG
TGCGGCGGCGACAAATCCACGCAGCGCGACGACATTCGCGCCGCCCATGCGATGCTCGAGCATCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT74605 WP_006398012.1 NZ_CP020398:2244243-2244542 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT74605 NZ_CP020398:2244243-2244542 [Burkholderia multivorans]
ATGAGCAAGATCAGCACGCGGCCGTGGGATTCGGCCGAACACCTGAAGACCGACGACGACATGGCCGAGTATTTCGAAGC
TTGCCTCCAGGAAGGCGGCGACGATCCGGCATTCATCGCGCACGCGCTCGGCGTGATCGCGCGCGCCCGCGGCATGTCGC
AAGTCGCGCGCGATGCGGGGCTATCGCGCGAGGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTCAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAAGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References