Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1096584..1097173 Replicon chromosome
Accession NZ_CP020398
Organism Burkholderia multivorans strain FDAARGOS_246

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A8H40_RS21865 Protein ID WP_006409935.1
Coordinates 1096754..1097173 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A8H40_RS21860 Protein ID WP_174328801.1
Coordinates 1096584..1096757 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H40_RS30785 1091666..1091809 - 144 WP_006409932.1 hypothetical protein -
A8H40_RS21840 1092398..1092601 + 204 WP_006403067.1 hypothetical protein -
A8H40_RS21845 1092615..1093298 - 684 WP_006409924.1 Fe2+-dependent dioxygenase -
A8H40_RS21850 1093295..1094050 - 756 WP_006403069.1 sel1 repeat family protein -
A8H40_RS21855 1094054..1096300 - 2247 WP_006403070.1 TonB-dependent siderophore receptor -
A8H40_RS21860 1096584..1096757 + 174 WP_174328801.1 plasmid stability protein Antitoxin
A8H40_RS21865 1096754..1097173 + 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
A8H40_RS21870 1097306..1098601 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
A8H40_RS21875 1098834..1098968 + 135 WP_006409923.1 entericidin A/B family lipoprotein -
A8H40_RS21880 1099062..1099637 - 576 WP_006409927.1 hypothetical protein -
A8H40_RS21885 1099841..1100791 - 951 WP_172488721.1 DMT family transporter -
A8H40_RS21890 1101282..1102076 - 795 WP_006409930.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T74600 WP_006409935.1 NZ_CP020398:1096754-1097173 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T74600 NZ_CP020398:1096754-1097173 [Burkholderia multivorans]
ATGATCCTTGTCGATACGAACGTCATTTTCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
CCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGAAGGAC
GCCGGCGGGACTGGCTGGAGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGGGCAAAGCCTATGCGCGCATTCGTGCGCACGCCCGTGCCGTCGGCAACGCGATCGCGCCGGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT74600 WP_174328801.1 NZ_CP020398:1096584-1096757 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT74600 NZ_CP020398:1096584-1096757 [Burkholderia multivorans]
CTGCACGGGCGCAGTACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTGGG
AACCTTGCTGGCGGAAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCGAACCGACCCGA
TGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References