Detailed information of TA system TA074598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2617563..2618263
• Replicon: chromosome
• Accession: NZ_CP020397
• Organism: Burkholderia multivorans strain FDAARGOS_246

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9BQB7
• Locus tag: A8H40_RS12910
• Protein ID: WP_006405634.1
• Coordinates: 2617563..2617940 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: A8H40_RS12915
• Protein ID: WP_006405635.1
• Coordinates: 2617940..2618263 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H40_RS12885	2613108..2613554	+	447	WP_006405630.1	VOC family protein	-
A8H40_RS12890	2613658..2615208	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
A8H40_RS12895	2615205..2615438	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
A8H40_RS12900	2615635..2616552	-	918	WP_006405631.1	spermidine synthase	-
A8H40_RS12905	2616780..2617034	+	255	WP_035488690.1	hypothetical protein	-
A8H40_RS12910	2617563..2617940	+	378	WP_006405634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8H40_RS12915	2617940..2618263	+	324	WP_006405635.1	helix-turn-helix domain-containing protein	Antitoxin
A8H40_RS12920	2618286..2618777	-	492	WP_006409760.1	DNA-deoxyinosine glycosylase	-
A8H40_RS12925	2618774..2619388	-	615	WP_006398690.1	chorismate lyase	-
A8H40_RS12930	2619397..2621295	-	1899	WP_006409758.1	molecular chaperone HtpG	-
A8H40_RS12935	2621454..2622914	-	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13564.63 Da
• Isoelectric Point: 9.7722

>T74598 WP_006405634.1 NZ_CP020397:2617563-2617940 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T74598 NZ_CP020397:2617563-2617940 [Burkholderia multivorans]
ATGGGTATAAATTCATCGATGGTTCCGTACACCAAACCGCTCTACTGGCTCGGCTCGGCACGCAAGCACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGTCTCGGATCGGCCGGCGTACTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACGCCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCAGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT74598 WP_006405635.1 NZ_CP020397:2617940-2618263 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT74598 NZ_CP020397:2617940-2618263 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTTGGCACGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGACTCGCAAATGGACGCAGCAGCACGCAGCACGATTGCTCGGCATGA
CGCAACCGAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGTGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTACAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Structures

Toxin

• AlphaFold DB: B9BQB7

Antitoxin

• AlphaFold DB: B9BQB8