Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 443601..444240 Replicon chromosome
Accession NZ_CP020394
Organism Burkholderia vietnamiensis strain FDAARGOS_239

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag A8H33_RS02690 Protein ID WP_011883463.1
Coordinates 443601..444020 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag A8H33_RS02695 Protein ID WP_011883461.1
Coordinates 444007..444240 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H33_RS02665 439024..439380 - 357 WP_011883473.1 BON domain-containing protein -
A8H33_RS02670 439849..441282 + 1434 WP_045579402.1 ABC transporter substrate-binding protein -
A8H33_RS02675 441377..442015 + 639 WP_011883469.1 2-hydroxychromene-2-carboxylate isomerase -
A8H33_RS02680 442085..443029 + 945 WP_011883467.1 LysR family transcriptional regulator -
A8H33_RS02685 443070..443471 - 402 WP_014722533.1 polyketide cyclase -
A8H33_RS02690 443601..444020 - 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
A8H33_RS02695 444007..444240 - 234 WP_011883461.1 DNA-binding protein Antitoxin
A8H33_RS02700 444567..445220 - 654 WP_045578499.1 xanthine dehydrogenase accessory protein XdhC -
A8H33_RS02705 445308..447680 - 2373 WP_045578500.1 xanthine dehydrogenase molybdopterin binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T74587 WP_011883463.1 NZ_CP020394:c444020-443601 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T74587 NZ_CP020394:c444020-443601 [Burkholderia vietnamiensis]
ATGTTTTTGGTTGATACCAACGTCATCAGCGAAGTACGGAAGCGGGAGCGAGCAGATAAAGGTGTGATGGCGTTTTTCCG
CAAGGCCGCGCAGGACGATGCCGATCTGTACCTTTCCGTGGTGACGGTTGGCGAACTGCGGCGCGGTGTGGAAATCATCC
GTCACCGTGGCGACAAGTCCCAGGCGACGCGCCTTGAAAACTGGCTCGATGGCGTACTTCGGGAGTTTGCGTCGAACATT
CTGGCGGTGGACGAAGAGATCGGGCAGTTGTGGGGACGCCTGCGCGTCCCGCATCCCGAGCACTCGCTCGACAAGTTGAT
CGCGGCAACGGCGTTGATCCACGACCTGATCGTCGTGACGCGGAACGTCGATGATTTCGCCGGAACGGGCGCACGCGTTC
TGAACCCATTCGAAAGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT74587 WP_011883461.1 NZ_CP020394:c444240-444007 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT74587 NZ_CP020394:c444240-444007 [Burkholderia vietnamiensis]
ATGGCAACTCTTCTGGTGAGAAATGTGGACGAGGAACTCGTCCAAAGCCTGCGCGAGCGGGCCGCAGCCAACGGGCGTAG
TGCGGAGGCCGAGCATCGAGAGATCCTGGCAAAGGCGCTGCGCGCGCCGCAGCGCAAGACGTTCGCGCAGGTGTTGATGA
GTATCCCGAACGTCGGAACCGATGCCGATTTTGCGCGCGTGGATGACGGCGAGGCAGCGAATGTTTTTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References