Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 900597..902353 Replicon chromosome
Accession NZ_CP020391
Organism Burkholderia thailandensis strain FDAARGOS_238

Toxin (Protein)


Gene name doc Uniprot ID Q2T555
Locus tag A8H32_RS03860 Protein ID WP_009900384.1
Coordinates 900597..901502 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q2T556
Locus tag A8H32_RS03865 Protein ID WP_009897321.1
Coordinates 901499..902353 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H32_RS03825 895992..897080 - 1089 WP_009900389.1 porin -
A8H32_RS03835 897515..897832 + 318 WP_009897336.1 non-heme iron oxygenase ferredoxin subunit -
A8H32_RS03840 897834..898145 + 312 WP_025405710.1 hypothetical protein -
A8H32_RS03845 898180..899247 + 1068 WP_019255252.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A8H32_RS03850 899244..900014 + 771 WP_019255253.1 SDR family oxidoreductase -
A8H32_RS03855 900053..900580 + 528 WP_009897327.1 cupin domain-containing protein -
A8H32_RS03860 900597..901502 + 906 WP_009900384.1 alpha/beta fold hydrolase Toxin
A8H32_RS03865 901499..902353 + 855 WP_009897321.1 IclR family transcriptional regulator Antitoxin
A8H32_RS03870 902350..903147 + 798 WP_009897318.1 SDR family oxidoreductase -
A8H32_RS03875 903140..904813 + 1674 WP_009900383.1 thiamine pyrophosphate-binding protein -
A8H32_RS03880 904806..905621 + 816 WP_009897315.1 aspartate dehydrogenase -
A8H32_RS03885 905643..907133 + 1491 WP_019255256.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-285)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30752.67 Da        Isoelectric Point: 8.4768

>T74586 WP_009900384.1 NZ_CP020391:900597-901502 [Burkholderia thailandensis]
MSAISTTTTDASATPFAALLERFAERRAAAGGARTIGYREAGAAYAAHAGRDPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGVSSRVAADSPVASDYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARQAGERLSGLLLISPAGGYGGAPA
DVRAERRDSRLALLASLGPQGLAAERSANMLSAQASDAARAWVRWNMARIVPAGYAQATHLLANADLASDLAHYRGRVAV
AVGADDTITPPAACERIARAAGAGLQVIPRAGHAGYVEAPDAYNALIDAFCRQCDGSRGAA

Download         Length: 906 bp

>T74586 NZ_CP020391:900597-901502 [Burkholderia thailandensis]
ATGAGCGCAATCTCCACGACGACTACCGATGCGAGCGCGACGCCGTTCGCCGCGCTGCTCGAACGCTTTGCCGAGCGGCG
CGCGGCCGCGGGCGGCGCGCGTACGATCGGCTATCGCGAAGCGGGCGCGGCGTACGCCGCGCATGCCGGGCGCGATCCCG
TCGTGTTGCTGCACGGGATCGGATCGGGTGCGGCGTCGTGGGTGCGTCAACTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCGCCCGGCTATGGCGTCTCGTCGCGCGTCGCGGCCGATTCGCCTGTCGCATCCGACTACGCGGCGTC
GCTCGCCGCGTGGCTAGACGCGCTGCGGATCGAACGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCGTCGCCGGCG
CGTTCGCGCGGCAAGCGGGCGAGCGTCTTTCGGGATTGCTGCTGATTTCTCCGGCGGGCGGCTACGGCGGCGCACCCGCC
GACGTGCGGGCCGAGCGGCGCGACAGCCGCCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCAAACATGCTGTCCGCGCAGGCGAGCGACGCCGCGCGCGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCCGCCG
GCTATGCGCAGGCGACGCACCTGCTCGCGAACGCGGACCTCGCTTCCGATCTCGCGCATTATCGCGGCCGCGTCGCGGTC
GCGGTCGGCGCCGACGATACGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCGCGGGCAGCGGGCGCCGGGTTGCAGGT
GATCCCGCGCGCGGGCCATGCCGGCTATGTCGAAGCGCCGGATGCATACAACGCGTTGATCGACGCATTTTGCCGTCAAT
GCGACGGATCGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31148.57 Da        Isoelectric Point: 6.9978

>AT74586 WP_009897321.1 NZ_CP020391:901499-902353 [Burkholderia thailandensis]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLTLAELRTLYPERALERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDASLVADGLIDKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT74586 NZ_CP020391:901499-902353 [Burkholderia thailandensis]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGCGCAACGATTCGAACTACGTCGTGCCTGGGCTCGAGCGCGGGCT
GCGGATCCTCGCCGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTGGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTC
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGTTTGCCGGTGATCGAGGG
CTTGCGCGACGCGACGGGCTTCACGGCGCACATCGTGATCCGCGACGGCCGCGATGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCACGCGACGACGCACGGCCACGTG
CTGATGGGCGACTTGACGCTCGCCGAGTTGCGCACGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGATGCGCTGTTCGACGTGATCCGTGCCGACGCGCGCCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAGGCGAGCCGGATCGTCGCAGTCGTCACGGTGACGGTGCCGAGG
CCGGAGATCGATGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTCGTGCGTGCGGCGGCCGAGCTGTCTCGGCGGCT
CAATTACCGGTCCGACGACGAAAACACCTACTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2T555

Antitoxin

Source ID Structure
AlphaFold DB Q2T556

References