Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5377489..5378143 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name cptA Uniprot ID A0A1Y4Y5C6
Locus tag A8H26_RS25575 Protein ID WP_043082125.1
Coordinates 5377489..5377896 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2C5WML2
Locus tag A8H26_RS25580 Protein ID WP_043082124.1
Coordinates 5377877..5378143 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS25555 5373488..5375221 - 1734 WP_043082128.1 single-stranded-DNA-specific exonuclease RecJ -
A8H26_RS25560 5375227..5375940 - 714 WP_048254078.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A8H26_RS25565 5375963..5376859 - 897 WP_045289036.1 site-specific tyrosine recombinase XerD -
A8H26_RS25570 5376958..5377479 + 522 WP_045289085.1 flavodoxin FldB -
A8H26_RS25575 5377489..5377896 - 408 WP_043082125.1 protein YgfX Toxin
A8H26_RS25580 5377877..5378143 - 267 WP_043082124.1 FAD assembly factor SdhE Antitoxin
A8H26_RS25585 5378391..5379374 + 984 WP_048254077.1 tRNA-modifying protein YgfZ -
A8H26_RS25590 5379426..5380268 + 843 WP_086499160.1 AraC family transcriptional regulator -
A8H26_RS25595 5380357..5381088 + 732 WP_043082122.1 AzlC family ABC transporter permease -
A8H26_RS25600 5381090..5381401 + 312 WP_048254075.1 AzlD domain-containing protein -
A8H26_RS25605 5381650..5382576 + 927 WP_048254115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15912.73 Da        Isoelectric Point: 10.9455

>T74582 WP_043082125.1 NZ_CP020388:c5377896-5377489 [Pluralibacter gergoviae]
VVLWQSDLRVSWRAQWISLLLHGVVAALVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRINASHGEIKLLTDARLRWQDQ
TWDILGTPWMLESGMMLRLRRLDNRKKSHLWIAADSMDAGEWRDLRRMLQQPSAQ

Download         Length: 408 bp

>T74582 NZ_CP020388:c5377896-5377489 [Pluralibacter gergoviae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCGCGCAGTGGATCTCTTTGCTGCTTCACGGCGTAGTCGCCGC
GCTGGTGTTGCTGATGCCCTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGTAGCCAGCGGCGTATTAACGCCAGCCACGGTGAAATCAAGCTGCTCACCGATGCCCGCCTGCGCTGGCAGGATCAG
ACGTGGGACATTCTGGGAACGCCGTGGATGCTTGAAAGCGGCATGATGCTGCGGCTGAGGCGGCTGGATAATCGCAAAAA
GAGCCATCTGTGGATCGCGGCTGACAGCATGGACGCGGGAGAGTGGCGGGATCTGCGCCGCATGCTTCAGCAGCCGTCGG
CGCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10499.02 Da        Isoelectric Point: 5.6950

>AT74582 WP_043082124.1 NZ_CP020388:c5378143-5377877 [Pluralibacter gergoviae]
MDINNKSRIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFIRLLECDDPDLFNWLMNHGKPADAGLQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT74582 NZ_CP020388:c5378143-5377877 [Pluralibacter gergoviae]
ATGGACATCAATAATAAGTCTCGAATCCACTGGGCGTGCCGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTTGAGTATGAATATGACTCCCTGAGTGATGACGACAAGCGGCTATTTATCCGCCTGCTGGAGTGTGACGACCCCGATC
TTTTCAACTGGCTGATGAATCACGGTAAGCCGGCGGATGCCGGGCTGCAACGGATGGTGCAACTTATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y4Y5C6

Antitoxin

Source ID Structure
AlphaFold DB A0A2C5WML2

References