Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 5250095..5250639 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name relE Uniprot ID A0A379CWM0
Locus tag A8H26_RS24955 Protein ID WP_048253394.1
Coordinates 5250364..5250639 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1S2BIB1
Locus tag A8H26_RS24950 Protein ID WP_048253393.1
Coordinates 5250095..5250367 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS24920 5245441..5246544 - 1104 WP_043082210.1 murein transglycosylase A -
A8H26_RS24940 5247166..5248419 - 1254 WP_048253392.1 N-acetylmuramoyl-L-alanine amidase AmiC -
A8H26_RS24945 5248646..5249977 + 1332 WP_043082208.1 amino-acid N-acetyltransferase -
A8H26_RS24950 5250095..5250367 + 273 WP_048253393.1 ribbon-helix-helix protein, CopG family Antitoxin
A8H26_RS24955 5250364..5250639 + 276 WP_048253394.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H26_RS24960 5250645..5252483 - 1839 WP_048253395.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.30 Da        Isoelectric Point: 9.8862

>T74581 WP_048253394.1 NZ_CP020388:5250364-5250639 [Pluralibacter gergoviae]
MRFQWSVPARNDVVRLHQFLADKNEAATANVVRSLINAPATLLLNPRRGEKIEGFEPREVRRAIIGSYEMHYELQNDVLI
VLRIWHQREDR

Download         Length: 276 bp

>T74581 NZ_CP020388:5250364-5250639 [Pluralibacter gergoviae]
ATGAGGTTTCAGTGGAGCGTACCAGCCAGAAACGATGTTGTCCGTCTGCACCAGTTTCTGGCCGATAAGAATGAGGCCGC
AACAGCAAATGTGGTCAGATCTCTGATTAACGCTCCCGCCACCCTACTGCTCAACCCTCGACGGGGAGAGAAAATAGAGG
GGTTTGAACCTCGCGAAGTGCGGCGCGCCATCATCGGCAGCTATGAAATGCATTATGAGCTGCAGAATGATGTATTAATT
GTTCTGCGCATCTGGCACCAGCGCGAGGATCGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10232.62 Da        Isoelectric Point: 4.9001

>AT74581 WP_048253393.1 NZ_CP020388:5250095-5250367 [Pluralibacter gergoviae]
MADMRTITAPLPIEMAESVDRWAEKHGRTRSWLVREAVGQFLARENERDRLIREALDAVDAGQLISHEDMVAWAESLGTD
KPLPPPEPRK

Download         Length: 273 bp

>AT74581 NZ_CP020388:5250095-5250367 [Pluralibacter gergoviae]
ATGGCTGATATGCGTACTATCACAGCTCCCCTGCCGATTGAGATGGCTGAAAGCGTCGATCGCTGGGCTGAAAAGCACGG
CCGCACCCGCTCATGGTTAGTCAGAGAAGCCGTTGGCCAATTTCTTGCGCGTGAAAATGAGCGCGATCGGCTGATACGCG
AGGCGCTTGACGCCGTCGATGCCGGACAGCTTATTTCTCATGAAGATATGGTCGCCTGGGCCGAATCACTCGGCACAGAT
AAGCCGCTCCCACCGCCGGAGCCGCGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379CWM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2BIB1

References