Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4980720..4981389 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag A8H26_RS23565 Protein ID WP_071883348.1
Coordinates 4980720..4981082 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag A8H26_RS23570 Protein ID WP_043082499.1
Coordinates 4981072..4981389 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS23545 4976795..4978345 + 1551 WP_045287224.1 membrane-bound lytic murein transglycosylase MltF -
A8H26_RS23550 4978342..4978872 - 531 WP_071883349.1 tRNA adenosine(34) deaminase TadA -
A8H26_RS23555 4978908..4979543 - 636 WP_048254444.1 phosphatidylglycerophosphatase C -
A8H26_RS23560 4979788..4980636 + 849 WP_048254442.1 MurR/RpiR family transcriptional regulator -
A8H26_RS23565 4980720..4981082 + 363 WP_071883348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8H26_RS23570 4981072..4981389 + 318 WP_043082499.1 helix-turn-helix domain-containing protein Antitoxin
A8H26_RS23575 4981569..4981829 + 261 WP_048254441.1 YfhL family 4Fe-4S dicluster ferredoxin -
A8H26_RS23580 4981826..4982206 - 381 WP_043082497.1 holo-ACP synthase -
A8H26_RS23585 4982206..4982937 - 732 WP_043082496.1 pyridoxine 5'-phosphate synthase -
A8H26_RS23590 4982958..4983683 - 726 WP_043082495.1 DNA repair protein RecO -
A8H26_RS23595 4983695..4984600 - 906 WP_045287229.1 GTPase Era -
A8H26_RS23600 4984597..4985277 - 681 WP_043082493.1 ribonuclease III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13417.17 Da        Isoelectric Point: 9.8076

>T74580 WP_071883348.1 NZ_CP020388:4980720-4981082 [Pluralibacter gergoviae]
ITQKSLYWVGSSRKDLQSLPDDVQDVFGYALYLAQTGSKHSQSKVLKGFGSAGVLEVVEQFFGSTYRAVYTVKFADAVYV
LHAFQKKSSSGIATPKCDLNKIHERLKAAEDHARRAHHER

Download         Length: 363 bp

>T74580 NZ_CP020388:4980720-4981082 [Pluralibacter gergoviae]
ATAACACAGAAATCTCTCTACTGGGTAGGTAGCAGCAGAAAGGATCTCCAGTCATTACCTGATGATGTGCAGGATGTATT
CGGCTATGCCCTGTATCTCGCTCAAACGGGCAGTAAACATTCTCAGAGCAAAGTGTTGAAAGGTTTTGGTAGCGCCGGAG
TGCTGGAGGTGGTTGAACAATTTTTCGGCAGCACCTATCGCGCTGTCTATACCGTAAAATTTGCCGATGCGGTCTATGTT
TTGCACGCATTTCAGAAGAAGTCCTCATCAGGGATCGCCACACCTAAATGCGATTTGAATAAGATTCATGAACGACTGAA
AGCCGCAGAGGATCATGCCAGGAGAGCGCACCATGAGCGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11384.28 Da        Isoelectric Point: 9.7905

>AT74580 WP_043082499.1 NZ_CP020388:4981072-4981389 [Pluralibacter gergoviae]
MSDNIEVSSGNVYTDLGDKSAEEMLIKAQLAAAIGQIIKSRGLTQEQAAKLIGLTQPKLSNLLRGQFRGISEAKMLECLT
RLGRDIEIVVSKPRQTPGSLKIIFA

Download         Length: 318 bp

>AT74580 NZ_CP020388:4981072-4981389 [Pluralibacter gergoviae]
ATGAGCGATAATATCGAAGTAAGCAGCGGTAACGTGTATACCGATCTGGGTGATAAATCTGCTGAAGAGATGCTGATCAA
AGCCCAGCTCGCTGCGGCTATCGGCCAAATCATTAAAAGTCGGGGCCTCACTCAGGAGCAGGCCGCAAAGCTGATTGGCC
TTACGCAACCAAAACTGTCAAACCTGCTGCGCGGTCAATTTCGCGGGATCAGCGAAGCAAAGATGCTGGAGTGTCTTACG
CGGCTGGGGCGCGATATCGAAATCGTGGTCAGCAAACCTCGCCAAACGCCGGGCAGTCTGAAAATAATCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References