Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2552219..2553117 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name - Uniprot ID A0A379D4Q7
Locus tag A8H26_RS12255 Protein ID WP_048253037.1
Coordinates 2552659..2553117 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0F0VT04
Locus tag A8H26_RS12250 Protein ID WP_045288665.1
Coordinates 2552219..2552662 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS12230 2547518..2548069 + 552 WP_043085211.1 replication initiation negative regulator SeqA -
A8H26_RS12235 2548098..2549738 + 1641 WP_043085209.1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -
A8H26_RS12240 2549807..2551258 - 1452 WP_048253035.1 MFS transporter -
A8H26_RS12245 2551358..2552164 + 807 WP_048253036.1 helix-turn-helix transcriptional regulator -
A8H26_RS12250 2552219..2552662 + 444 WP_045288665.1 DUF2384 domain-containing protein Antitoxin
A8H26_RS12255 2552659..2553117 + 459 WP_048253037.1 RES family NAD+ phosphorylase Toxin
A8H26_RS12260 2553141..2554046 + 906 WP_048253038.1 alpha/beta hydrolase -
A8H26_RS12265 2554016..2554900 - 885 WP_043085201.1 EamA family transporter RarD -
A8H26_RS12270 2555130..2555432 - 303 WP_043085200.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS -
A8H26_RS12275 2555455..2555628 - 174 WP_071883418.1 GhoT/OrtT family toxin -
A8H26_RS12280 2555712..2557028 - 1317 WP_106912821.1 putrescine-ornithine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16900.55 Da        Isoelectric Point: 5.7172

>T74568 WP_048253037.1 NZ_CP020388:2552659-2553117 [Pluralibacter gergoviae]
VIFYRLTKTRYLMSAWSGQGAREAGGRWNSVGTAMVYLSQMASLTMLETLVHLQAPQLLDAFTLLSIEIPDEQIQTLDRQ
RLPETWSGEEAPAQLALIGDAWIASGVSLALRVPSALSPVEDNCLLNPQHPALFDMMAGVKRIPFRFDTRLK

Download         Length: 459 bp

>T74568 NZ_CP020388:2552659-2553117 [Pluralibacter gergoviae]
GTGATCTTCTACCGGCTGACCAAGACGCGCTATCTGATGAGCGCCTGGTCGGGGCAGGGCGCCCGCGAAGCCGGAGGGCG
CTGGAACAGCGTCGGCACGGCGATGGTCTACCTGTCGCAGATGGCGTCGCTGACGATGCTGGAGACGCTGGTGCACCTCC
AGGCCCCGCAGCTGCTGGACGCCTTCACGCTGCTCAGCATTGAGATCCCGGACGAACAGATCCAGACCCTCGACAGGCAG
CGGCTGCCCGAAACCTGGTCCGGCGAAGAGGCGCCAGCCCAGCTGGCCCTGATCGGCGATGCGTGGATAGCCAGCGGCGT
ATCGCTGGCGCTGCGGGTGCCCAGCGCGCTCTCACCGGTAGAAGACAACTGTTTACTCAATCCTCAGCATCCTGCACTCT
TCGACATGATGGCCGGCGTGAAGAGAATTCCTTTCCGGTTTGATACGCGCCTTAAATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16440.81 Da        Isoelectric Point: 8.5740

>AT74568 WP_045288665.1 NZ_CP020388:2552219-2552662 [Pluralibacter gergoviae]
MKLYSPTVTADKSHDPWRAVGLGTGDGIELMGQISLGLEGDVARRISEWADITPAELRRMSGIPNTTFNRSIKARFTAEQ
SERLVRIVRVLERAVDLFEGDKRAAQKWMSEPNRALGWKAPAEVVFSETGALEVMRLITRLEHGVYS

Download         Length: 444 bp

>AT74568 NZ_CP020388:2552219-2552662 [Pluralibacter gergoviae]
ATGAAACTCTACTCACCCACCGTTACCGCCGACAAATCTCACGACCCGTGGCGCGCCGTAGGCCTCGGTACCGGCGACGG
TATTGAATTAATGGGGCAGATAAGCCTCGGCCTGGAGGGCGATGTCGCACGGCGCATCTCCGAGTGGGCAGATATCACCC
CGGCGGAGCTGCGCAGGATGTCCGGCATTCCCAATACCACTTTCAACCGCAGCATTAAGGCCCGCTTTACCGCCGAACAG
AGCGAGCGGCTGGTGCGCATTGTGCGCGTGCTGGAGCGCGCGGTAGATCTGTTTGAAGGCGATAAGCGCGCCGCGCAGAA
GTGGATGAGCGAGCCAAACCGCGCGCTGGGCTGGAAAGCGCCCGCAGAGGTCGTCTTCTCTGAAACCGGCGCGCTGGAGG
TGATGCGCCTGATAACCCGGCTGGAGCACGGAGTCTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379D4Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0VT04

References