Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2265184..2266743 Replicon chromosome
Accession NZ_CP020388
Organism Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A8H26_RS10930 Protein ID WP_048253659.1
Coordinates 2265433..2266743 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A8H26_RS10925 Protein ID WP_048253660.1
Coordinates 2265184..2265432 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8H26_RS10910 2261959..2262603 + 645 WP_045288158.1 adenylate kinase -
A8H26_RS10915 2262733..2263695 + 963 WP_043085547.1 ferrochelatase -
A8H26_RS10920 2263765..2265066 + 1302 Protein_2084 inosine/guanosine kinase -
A8H26_RS10925 2265184..2265432 + 249 WP_048253660.1 helix-turn-helix domain-containing protein Antitoxin
A8H26_RS10930 2265433..2266743 + 1311 WP_048253659.1 type II toxin-antitoxin system HipA family toxin Toxin
A8H26_RS10935 2266770..2268443 - 1674 WP_043085543.1 Kef family K(+) transporter -
A8H26_RS10940 2268675..2269895 - 1221 WP_043085542.1 MFS transporter -
A8H26_RS10945 2270071..2271723 + 1653 WP_048253658.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49262.49 Da        Isoelectric Point: 6.6615

>T74567 WP_048253659.1 NZ_CP020388:2265433-2266743 [Pluralibacter gergoviae]
MKSLSVYMNGYLVGTLGMEPGGANLFTYHQSWLNTPQARPVSLSLPLRERSYDGEVVFNFFDNLLPDSREIRERIAARYH
ADSLRPFDLLYEIGRDCVGAVILQPPDEAIQDIQHIYSERLNEAQLDAILTGYLSTTRFRQQEIPDFRISIAGAQEKTAL
LHYQGDWQVPKGITPTTHIFKLPVGEIQGHSFTLDLRDSVENEWLSMLLARLYGFEVPDCEIVLTQNTKALAVRRFDRRF
VDGERWIARLPQEDMCQALGVSSSKKYESDGGPGIEAIMRFLLGSDAAEQDRETFMRSHILFWLLAASDGHAKNYSVAIL
PGGGYRLTPLYDIMSCYPLIGGRGLAKQDIKMAMALTATGRGKKYEWSTIFPRHFIATAKKCGFSEERMVELLREFGEQT
PRVLAEAARLLPKDFPQHISEAIFLGVSKAAKRLMV

Download         Length: 1311 bp

>T74567 NZ_CP020388:2265433-2266743 [Pluralibacter gergoviae]
ATGAAAAGCCTGTCGGTGTACATGAATGGCTATTTAGTCGGCACGCTGGGCATGGAGCCTGGCGGGGCAAATCTGTTTAC
CTATCACCAAAGCTGGCTGAATACGCCGCAGGCTCGCCCCGTATCGCTGTCCTTACCTTTACGCGAGCGGTCCTATGACG
GGGAGGTCGTCTTTAATTTTTTTGACAATCTGCTTCCCGACAGTCGCGAAATCCGCGAGCGTATTGCCGCCCGCTATCAC
GCTGACTCTCTGCGTCCGTTCGATCTTTTGTATGAGATCGGACGCGACTGCGTCGGCGCGGTGATCCTTCAGCCTCCTGA
TGAGGCTATCCAGGATATACAGCATATTTACAGTGAACGTCTGAATGAGGCTCAGCTGGACGCGATCCTAACAGGGTATC
TGAGCACCACTCGCTTTCGTCAGCAGGAAATACCGGATTTTCGAATCTCCATCGCAGGGGCCCAGGAGAAAACGGCACTC
CTTCACTATCAGGGCGACTGGCAGGTTCCGAAGGGAATTACGCCAACGACCCATATTTTTAAACTGCCTGTTGGTGAAAT
TCAGGGGCACAGTTTTACGCTTGACCTGCGCGATAGCGTTGAGAATGAGTGGCTAAGTATGCTGCTCGCCCGGCTATATG
GCTTCGAGGTCCCAGATTGCGAAATCGTGTTAACCCAAAATACCAAAGCGTTAGCCGTGCGCCGTTTTGATCGCCGTTTT
GTAGACGGTGAACGCTGGATTGCCCGTCTGCCGCAGGAGGATATGTGTCAGGCGCTTGGTGTCTCTTCGTCAAAAAAATA
TGAGAGCGACGGCGGGCCGGGAATTGAGGCGATAATGCGATTTTTACTGGGCTCTGATGCTGCGGAGCAGGATCGGGAAA
CGTTTATGCGCAGCCACATTCTTTTTTGGCTACTGGCGGCAAGCGACGGTCATGCGAAGAACTACTCTGTGGCTATTCTT
CCGGGAGGCGGCTATCGGCTGACGCCTCTTTACGACATCATGTCCTGCTACCCATTAATTGGCGGCCGCGGTCTGGCAAA
GCAGGATATTAAGATGGCGATGGCGCTCACGGCCACCGGACGCGGAAAGAAGTATGAATGGAGCACTATTTTTCCTCGCC
ACTTTATCGCTACAGCTAAAAAATGCGGCTTCAGTGAAGAGCGCATGGTGGAGCTGCTGCGGGAATTTGGTGAACAAACG
CCGCGAGTTTTAGCCGAGGCCGCGCGTTTGCTTCCCAAGGATTTTCCGCAGCACATCAGTGAAGCAATCTTTCTCGGCGT
CAGTAAAGCCGCCAAACGCCTGATGGTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9557.91 Da        Isoelectric Point: 10.0512

>AT74567 WP_048253660.1 NZ_CP020388:2265184-2265432 [Pluralibacter gergoviae]
MKITSPAQLAIYLKDRRKQQKQAQSTVAERVGLRQDTVSKFENSPDKSQIDTLFKILSSLNMELHLEPREAKKAEQGWKE
EW

Download         Length: 249 bp

>AT74567 NZ_CP020388:2265184-2265432 [Pluralibacter gergoviae]
ATGAAAATTACCTCACCAGCGCAGCTGGCCATCTACCTCAAGGACCGCAGAAAGCAGCAGAAGCAGGCGCAGAGCACCGT
CGCCGAACGGGTTGGCCTGCGTCAGGACACGGTGTCTAAATTTGAGAACAGTCCCGATAAGAGCCAGATTGATACCCTGT
TTAAAATCCTCTCCTCGCTAAATATGGAGCTGCACCTTGAACCCAGAGAGGCGAAAAAGGCGGAGCAGGGCTGGAAAGAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References