Detailed information of TA system TA074565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1921683..1922403
• Replicon: chromosome
• Accession: NZ_CP020388
• Organism: Pluralibacter gergoviae strain FDAARGOS_186

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1Y4XQ46
• Locus tag: A8H26_RS09255
• Protein ID: WP_045287565.1
• Coordinates: 1922005..1922403 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A8H26_RS09250
• Protein ID: WP_045287566.1
• Coordinates: 1921683..1922012 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8H26_RS09240	1918044..1919933	+	1890	WP_048253164.1	pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase	-
A8H26_RS09245	1920134..1921558	+	1425	WP_043086785.1	dihydrolipoyl dehydrogenase	-
A8H26_RS09250	1921683..1922012	-	330	WP_045287566.1	helix-turn-helix domain-containing protein	Antitoxin
A8H26_RS09255	1922005..1922403	-	399	WP_045287565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A8H26_RS09260	1922660..1923565	-	906	WP_048253163.1	LysR family transcriptional regulator	-
A8H26_RS09265	1923664..1924659	+	996	WP_048253262.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14899.16 Da
• Isoelectric Point: 9.7433

>T74565 WP_045287565.1 NZ_CP020388:c1922403-1922005 [Pluralibacter gergoviae]
VRVFRTKLFNKGAKNFQLPDTALFAVAREVFEGRYEANLGGGVIKKRIAINGKGKRGGIRSIIFFKVGSHIFFADTWSKN
DTPKSGKEIDDAQLYAYRLLAETLLNLNDKQLIEMIAKNLLTEVKECEDTDE

Nucleotide

• Length: 399 bp

>T74565 NZ_CP020388:c1922403-1922005 [Pluralibacter gergoviae]
GTGAGGGTTTTTCGAACTAAGCTATTCAATAAGGGAGCAAAAAATTTCCAGCTCCCTGACACAGCATTATTCGCCGTTGC
CAGGGAGGTCTTTGAAGGTCGGTATGAAGCCAATCTCGGCGGTGGCGTGATTAAGAAACGCATAGCGATCAACGGGAAAG
GAAAGCGCGGAGGTATTCGCAGCATCATCTTTTTTAAAGTTGGCAGCCATATTTTCTTCGCCGACACGTGGAGTAAAAAC
GATACGCCCAAGAGCGGTAAAGAGATTGATGATGCACAACTCTATGCGTATCGATTGCTGGCAGAAACATTGCTTAATCT
GAACGACAAACAGTTAATAGAGATGATTGCAAAGAACCTGCTCACTGAAGTCAAAGAATGTGAGGATACTGATGAGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12010.96 Da
• Isoelectric Point: 9.6557

>AT74565 WP_045287566.1 NZ_CP020388:c1922012-1921683 [Pluralibacter gergoviae]
MSDKMTDILEFSKELNNAGILSDDKYAKINARAKACKITAQIQPLRPMSGEEIRTMRSHYGMSQTMLAATLGITTASVSK
WERDVVQPSGPALRLLNTLQLKGPDIFIA

Nucleotide

• Length: 330 bp

>AT74565 NZ_CP020388:c1922012-1921683 [Pluralibacter gergoviae]
ATGAGTGATAAAATGACCGATATTCTTGAGTTCTCAAAAGAGCTCAATAACGCCGGGATCCTGAGCGATGATAAGTACGC
GAAAATTAATGCCCGAGCCAAAGCGTGTAAAATAACGGCGCAAATCCAGCCTCTCAGGCCGATGAGCGGTGAAGAAATAA
GGACAATGCGCAGCCACTACGGCATGTCCCAAACAATGCTGGCCGCCACCCTTGGCATAACGACCGCAAGCGTTTCGAAA
TGGGAACGTGATGTTGTACAACCCAGCGGCCCGGCGCTGCGCTTATTGAACACGCTGCAGCTTAAAGGGCCCGATATTTT
TATCGCATAG

Structures

Toxin

• AlphaFold DB: A0A1Y4XQ46