Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1655959..1657521 Replicon chromosome
Accession NZ_CP020384
Organism Rhodovulum sp. MB263

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B5V46_RS07860 Protein ID WP_080616084.1
Coordinates 1656211..1657521 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B5V46_RS07855 Protein ID WP_080616083.1
Coordinates 1655959..1656210 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5V46_RS07800 1651045..1651260 + 216 Protein_1569 IS110 family transposase -
B5V46_RS07805 1651594..1651923 - 330 WP_080616073.1 bacteriophage spanin2 family protein -
B5V46_RS07810 1651932..1652429 - 498 WP_080616074.1 lysozyme -
B5V46_RS07815 1652434..1652646 - 213 WP_080616075.1 hypothetical protein -
B5V46_RS07820 1652746..1653057 - 312 WP_080616076.1 hypothetical protein -
B5V46_RS07825 1653062..1653520 - 459 WP_080616077.1 hypothetical protein -
B5V46_RS07830 1653520..1653972 - 453 WP_080616078.1 hypothetical protein -
B5V46_RS07835 1654161..1654346 + 186 WP_080616079.1 type II toxin-antitoxin system HicA family toxin -
B5V46_RS07840 1654363..1654755 + 393 WP_080616080.1 type II toxin-antitoxin system HicB family antitoxin -
B5V46_RS07845 1654764..1655360 - 597 WP_080616081.1 hypothetical protein -
B5V46_RS07850 1655624..1655818 + 195 WP_080616082.1 hypothetical protein -
B5V46_RS07855 1655959..1656210 + 252 WP_080616083.1 helix-turn-helix transcriptional regulator Antitoxin
B5V46_RS07860 1656211..1657521 + 1311 WP_080616084.1 type II toxin-antitoxin system HipA family toxin Toxin
B5V46_RS20205 1657683..1657925 - 243 Protein_1582 hypothetical protein -
B5V46_RS20210 1657925..1658176 + 252 Protein_1583 zinc ribbon domain-containing protein -
B5V46_RS20215 1658180..1658458 - 279 WP_080616085.1 hypothetical protein -
B5V46_RS07880 1658984..1660330 + 1347 WP_080616086.1 ABC transporter substrate-binding protein -
B5V46_RS07885 1660391..1661314 + 924 WP_080616087.1 branched-chain amino acid ABC transporter permease -
B5V46_RS07890 1661311..1662252 + 942 WP_080616088.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1639656..1665956 26300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48800.62 Da        Isoelectric Point: 5.5692

>T74556 WP_080616084.1 NZ_CP020384:1656211-1657521 [Rhodovulum sp. MB263]
MGRRRSFAPLNVFLNTRLVGQLLREKSGAISFAYDRSWLEWEHRMPISLSLPLREDRFLGGEAIPVFDNLLPDNPTIRRR
VAERVGAAGTDAFSLLSEIGRDCVGALQFLPDGEEPQPQDRLTGEPVDETQIEAILNDLDRTPLGIRKERDFRISVAGAQ
EKTALLFHDGQWIEPSGTTPTTHIIKPQIGRLPNGMDLSNSVENEYFCLKLIQGFGLRAAEAEIATLGARKALVVERFDR
LWTKDGRLIRLPQEDMCQALSVPSPQKYQNEGGPGIVDIMDILRGSDEPTQDRLDFFKANILFWLIGATDGHAKNFSIGL
LPGGRFRLTPFYDVMTVQPTFDAGEIQRKDFRLAMRLGKSRHYRVMDIVGRHFRETGLQAGLSRQAIDDVFAEIRATTVA
AIAATVDALPNGFPEEIATSVQGEIYKRLEQLTDKT

Download         Length: 1311 bp

>T74556 NZ_CP020384:1656211-1657521 [Rhodovulum sp. MB263]
ATGGGTCGCCGCCGCAGCTTTGCACCGTTGAACGTCTTCCTGAACACGCGACTCGTCGGACAGCTCCTGCGCGAGAAGTC
GGGGGCGATCAGCTTTGCCTATGACCGCTCGTGGCTGGAGTGGGAGCATCGGATGCCGATCTCTCTCTCCCTGCCCTTGC
GGGAAGACCGCTTTCTCGGTGGTGAAGCCATCCCCGTCTTCGACAACTTGCTGCCCGACAACCCGACGATCCGCCGCCGC
GTGGCGGAACGGGTCGGCGCAGCGGGCACGGATGCCTTCAGCCTCCTCTCTGAAATCGGCCGCGACTGTGTCGGGGCATT
GCAGTTTCTGCCCGATGGCGAAGAGCCCCAGCCACAGGACAGGCTGACGGGCGAACCGGTCGATGAGACGCAAATCGAGG
CGATCCTGAACGATCTGGACAGGACGCCGCTTGGCATCCGCAAGGAAAGGGATTTCCGGATATCGGTGGCGGGCGCTCAG
GAAAAGACGGCCTTGTTGTTCCATGACGGCCAGTGGATCGAGCCCTCGGGCACAACGCCGACGACACATATTATCAAGCC
GCAGATCGGACGCCTGCCCAACGGCATGGATTTGTCGAACAGCGTCGAGAACGAGTATTTCTGCCTGAAGCTGATACAGG
GCTTCGGCCTCCGTGCGGCAGAGGCCGAAATCGCGACATTAGGCGCGCGCAAAGCCCTCGTCGTCGAACGTTTCGACCGG
CTCTGGACGAAGGACGGTCGCCTTATCCGTCTGCCGCAAGAGGATATGTGTCAGGCGCTTTCGGTGCCCTCGCCGCAAAA
ATATCAGAATGAAGGCGGTCCCGGCATTGTCGACATCATGGACATACTGCGCGGAAGTGACGAGCCGACACAGGATCGGC
TGGACTTCTTCAAGGCCAATATCCTGTTCTGGCTGATTGGCGCGACCGATGGCCATGCCAAGAATTTCAGCATCGGGTTG
CTGCCCGGCGGGCGGTTCCGCCTGACGCCATTCTATGACGTGATGACGGTGCAGCCGACATTCGATGCCGGAGAGATTCA
GCGTAAGGATTTCAGGCTAGCGATGCGCCTGGGCAAGTCGCGTCACTACAGGGTCATGGACATCGTAGGGCGGCATTTCC
GCGAAACCGGCCTGCAAGCAGGGCTCTCGCGCCAAGCCATCGACGACGTCTTCGCCGAAATCAGAGCGACCACCGTGGCA
GCCATCGCGGCGACGGTCGACGCCCTCCCGAACGGCTTTCCAGAAGAGATCGCGACATCAGTTCAGGGCGAGATTTACAA
ACGTTTAGAACAACTTACAGACAAAACTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9158.49 Da        Isoelectric Point: 9.8942

>AT74556 WP_080616083.1 NZ_CP020384:1655959-1656210 [Rhodovulum sp. MB263]
MKQLARTPKDIGHAIREARKAKGFTQKDLAAKSGVWQETISKIENGVASTKLETLFDLFAALDLEIQVQPRSKGSQSGLE
DIF

Download         Length: 252 bp

>AT74556 NZ_CP020384:1655959-1656210 [Rhodovulum sp. MB263]
ATGAAGCAGTTAGCACGCACCCCCAAAGACATCGGCCACGCCATCCGTGAAGCACGGAAGGCAAAGGGCTTCACACAAAA
AGACCTCGCTGCCAAAAGCGGGGTCTGGCAGGAGACCATCTCCAAGATCGAGAATGGCGTCGCCAGCACCAAGCTGGAAA
CGCTCTTCGATCTGTTCGCCGCGCTCGACCTCGAAATCCAGGTGCAGCCAAGAAGCAAGGGGTCGCAAAGCGGCCTGGAG
GACATCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References