Detailed information of TA system TA074555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1654161..1654755
• Replicon: chromosome
• Accession: NZ_CP020384
• Organism: Rhodovulum sp. MB263

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: B5V46_RS07835
• Protein ID: WP_080616079.1
• Coordinates: 1654161..1654346 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: B5V46_RS07840
• Protein ID: WP_080616080.1
• Coordinates: 1654363..1654755 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5V46_RS07790	1649524..1650408	+	885	WP_080617988.1	follicular epithelium yolk protein subunit	-
B5V46_RS19710	1650739..1650958	+	220	Protein_1568	transposase	-
B5V46_RS07800	1651045..1651260	+	216	Protein_1569	IS110 family transposase	-
B5V46_RS07805	1651594..1651923	-	330	WP_080616073.1	bacteriophage spanin2 family protein	-
B5V46_RS07810	1651932..1652429	-	498	WP_080616074.1	lysozyme	-
B5V46_RS07815	1652434..1652646	-	213	WP_080616075.1	hypothetical protein	-
B5V46_RS07820	1652746..1653057	-	312	WP_080616076.1	hypothetical protein	-
B5V46_RS07825	1653062..1653520	-	459	WP_080616077.1	hypothetical protein	-
B5V46_RS07830	1653520..1653972	-	453	WP_080616078.1	hypothetical protein	-
B5V46_RS07835	1654161..1654346	+	186	WP_080616079.1	type II toxin-antitoxin system HicA family toxin	Toxin
B5V46_RS07840	1654363..1654755	+	393	WP_080616080.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
B5V46_RS07845	1654764..1655360	-	597	WP_080616081.1	hypothetical protein	-
B5V46_RS07850	1655624..1655818	+	195	WP_080616082.1	hypothetical protein	-
B5V46_RS07855	1655959..1656210	+	252	WP_080616083.1	helix-turn-helix transcriptional regulator	-
B5V46_RS07860	1656211..1657521	+	1311	WP_080616084.1	type II toxin-antitoxin system HipA family toxin	-
B5V46_RS20205	1657683..1657925	-	243	Protein_1582	hypothetical protein	-
B5V46_RS20210	1657925..1658176	+	252	Protein_1583	zinc ribbon domain-containing protein	-
B5V46_RS20215	1658180..1658458	-	279	WP_080616085.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1639656..1665956	26300

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7041.28 Da
• Isoelectric Point: 11.0108

>T74555 WP_080616079.1 NZ_CP020384:1654161-1654346 [Rhodovulum sp. MB263]
MLETNSRKIVKRLEQDGFELVKVTGSHPKFRKGDRIVTIPHPKKDLPIGTVRNIYKQAGWL

Nucleotide

• Length: 186 bp

>T74555 NZ_CP020384:1654161-1654346 [Rhodovulum sp. MB263]
ATGCTCGAGACCAACAGCCGCAAGATCGTCAAGCGTCTCGAGCAAGACGGCTTCGAGCTGGTGAAGGTCACCGGGTCGCA
CCCCAAGTTTCGCAAGGGCGACAGGATCGTGACGATCCCCCACCCGAAGAAGGACCTGCCCATCGGCACGGTCCGCAACA
TCTACAAACAGGCCGGCTGGCTGTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 13891.67 Da
• Isoelectric Point: 4.4859

>AT74555 WP_080616080.1 NZ_CP020384:1654363-1654755 [Rhodovulum sp. MB263]
MRHYIGVVHQEDDSAFGIHFPDVPGCFSAADALDDLLSNASEALALHLEDEVLPEARSLDAVRADSDVARDLEAGAFLLA
VPFFRLSGRTAKANITMDAGLLAAIDQTAKARGLTRSAFLADLARREIIG

Nucleotide

• Length: 393 bp

>AT74555 NZ_CP020384:1654363-1654755 [Rhodovulum sp. MB263]
ATGCGTCACTACATCGGCGTCGTGCACCAGGAAGACGACAGCGCCTTCGGCATCCATTTCCCCGACGTGCCCGGCTGCTT
CTCGGCCGCCGATGCGCTCGACGATCTTCTGTCCAATGCCAGCGAGGCGCTCGCGCTTCATCTCGAGGACGAGGTCCTGC
CCGAGGCGCGCAGCCTCGATGCCGTTCGCGCCGACAGCGACGTGGCCCGCGACCTCGAGGCGGGGGCCTTCCTTCTGGCG
GTGCCGTTCTTCCGCCTGAGCGGGCGGACCGCCAAGGCGAATATCACCATGGATGCGGGGCTGCTGGCAGCCATCGACCA
GACGGCGAAGGCGCGCGGGCTGACCCGCTCGGCCTTCCTGGCCGATCTGGCGCGGCGCGAGATCATCGGCTGA