Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2206207..2206751 Replicon chromosome
Accession NZ_CP020381
Organism Mycobacterium tuberculosis strain MTB1

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag B5817_RS10640 Protein ID WP_003409896.1
Coordinates 2206207..2206503 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag B5817_RS10645 Protein ID WP_003409899.1
Coordinates 2206500..2206751 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5817_RS10585 2201240..2201590 - 351 WP_003899096.1 hypothetical protein -
B5817_RS10590 2201601..2202503 - 903 WP_003899097.1 hypothetical protein -
B5817_RS10595 2202524..2202715 - 192 WP_003409876.1 hypothetical protein -
B5817_RS10600 2202716..2203012 - 297 WP_003409877.1 hypothetical protein -
B5817_RS10605 2203252..2203467 + 216 WP_003409878.1 antitoxin -
B5817_RS10610 2203464..2203775 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
B5817_RS21965 2203749..2204270 - 522 WP_003904745.1 hypothetical protein -
B5817_RS10620 2204245..2204622 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
B5817_RS10625 2204664..2205113 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
B5817_RS10630 2205110..2205655 + 546 WP_003409891.1 SecB-like chaperone -
B5817_RS10635 2205544..2206158 - 615 WP_003901296.1 hypothetical protein -
B5817_RS10640 2206207..2206503 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5817_RS10645 2206500..2206751 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
B5817_RS10650 2206738..2207232 + 495 WP_003899099.1 hypothetical protein -
B5817_RS10655 2207392..2207799 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
B5817_RS10660 2207803..2208075 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
B5817_RS10665 2208108..2209328 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
B5817_RS10680 2210227..2211024 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T74524 WP_003409896.1 NZ_CP020381:c2206503-2206207 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T74524 NZ_CP020381:c2206503-2206207 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT74524 WP_003409899.1 NZ_CP020381:c2206751-2206500 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT74524 NZ_CP020381:c2206751-2206500 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References