74459

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3198587..3199687 Replicon chromosome
Accession NZ_CP020373
Organism Shewanella khirikhana strain TH2012

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag STH12_RS13990 Protein ID WP_126168107.1
Coordinates 3198587..3199324 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag STH12_RS13995 Protein ID WP_126168108.1
Coordinates 3199325..3199687 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STH12_RS13965 3194950..3195369 + 420 WP_126168103.1 CBS domain-containing protein -
STH12_RS13970 3195502..3196191 - 690 WP_126169532.1 LrgB family protein -
STH12_RS13975 3196200..3196670 - 471 WP_126168104.1 CidA/LrgA family protein -
STH12_RS13980 3196773..3197663 + 891 WP_126168105.1 LysR family transcriptional regulator -
STH12_RS13985 3197762..3198571 - 810 WP_126168106.1 hypothetical protein -
STH12_RS13990 3198587..3199324 - 738 WP_126168107.1 RES family NAD+ phosphorylase Toxin
STH12_RS13995 3199325..3199687 - 363 WP_126168108.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
STH12_RS14000 3199957..3200610 + 654 WP_126168109.1 oxygen-insensitive NAD(P)H nitroreductase -
STH12_RS14005 3200755..3201405 + 651 WP_126168110.1 DnaJ domain-containing protein -
STH12_RS14010 3201590..3202342 + 753 WP_126168111.1 DsbA family protein -
STH12_RS14015 3202821..3204152 + 1332 WP_126168112.1 Na+/H+ antiporter NhaC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(59-194)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-118)


Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28129.96 Da        Isoelectric Point: 4.7665

>T74459 WP_126168107.1 NZ_CP020373:c3199324-3198587 [Shewanella khirikhana]
MKPSIPSSCLNRPYSGSCYRLVESQEEAATLSLVDNFDEQMMLESLLDDAKPPYRDGTEHLHYLLKSPFRYPPLRHGSRF
GTRLMPSFFYASETVATCLAEVAYYRFVFLQDMAEPFEGVLRSEHMVFRVELATERCADLTLIDDLDIQASLTHQSDYQY
TQQLGGMLVDERCQLIRSYSARDFGGINLAVVDPLVFCSGPLDQSLWICQLEPDRLAFTERGRGHLPRYFELQQFMQDGR
LPRPA

Download         Length: 738 bp

>T74459 NZ_CP020373:c3199324-3198587 [Shewanella khirikhana]
ATGAAGCCGAGCATTCCTTCGTCGTGCCTCAATCGCCCCTATTCGGGCAGCTGCTATCGCTTGGTGGAGTCTCAGGAAGA
GGCGGCCACCTTGAGCCTGGTGGATAATTTTGATGAGCAGATGATGCTCGAAAGCCTGCTGGATGACGCCAAGCCGCCGT
ACCGCGACGGCACCGAACATCTGCATTATCTGCTCAAGTCCCCGTTTCGTTATCCGCCGCTGCGTCACGGCTCCCGTTTC
GGTACCCGGCTGATGCCCAGCTTCTTTTATGCCAGTGAAACCGTTGCGACCTGCCTTGCCGAGGTGGCCTATTACCGCTT
TGTGTTTTTGCAGGATATGGCCGAGCCTTTTGAAGGCGTGCTGCGTTCGGAGCACATGGTGTTTCGGGTTGAGCTTGCCA
CTGAGCGCTGCGCCGATCTTACTCTTATCGACGACCTGGATATTCAGGCCAGCCTTACCCATCAAAGCGACTATCAATAC
ACTCAGCAGCTTGGCGGGATGCTGGTGGATGAGCGTTGCCAGTTGATCCGCAGCTACTCGGCCAGAGACTTTGGTGGGAT
AAACCTTGCGGTAGTCGATCCTTTGGTATTTTGTTCTGGCCCTTTGGATCAGAGTTTGTGGATCTGTCAGCTCGAACCTG
ACAGACTTGCGTTTACCGAACGGGGGCGGGGACACCTGCCCCGCTATTTTGAGTTACAACAGTTTATGCAGGATGGGCGC
TTGCCCCGACCTGCCTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13035.96 Da        Isoelectric Point: 10.2284

>AT74459 WP_126168108.1 NZ_CP020373:c3199687-3199325 [Shewanella khirikhana]
MSAIAKPTASTVLFKAFINACHALELSNSEASHIIGVNPSTLSRNASQGFKPESKQGELQLQLVRLYRSLYAIAGGQQDF
MRHWINSPNHALGGTPRELVKSVVGLVSVNQYLDAMRGKV

Download         Length: 363 bp

>AT74459 NZ_CP020373:c3199687-3199325 [Shewanella khirikhana]
ATGTCCGCGATAGCCAAACCCACAGCATCCACTGTGCTGTTCAAAGCCTTTATTAATGCCTGCCATGCGCTCGAGCTGAG
CAATAGCGAGGCCAGCCATATTATTGGGGTGAACCCCAGCACCCTGAGCCGCAATGCCTCTCAGGGGTTTAAGCCTGAGT
CCAAACAGGGCGAGCTGCAATTACAACTGGTGCGGCTTTATCGCTCGCTGTATGCCATCGCCGGTGGCCAGCAGGACTTT
ATGCGCCACTGGATAAACAGCCCCAACCATGCCCTGGGGGGCACGCCGCGGGAACTGGTGAAATCCGTGGTGGGCCTGGT
GAGTGTGAATCAGTATCTGGATGCCATGCGTGGCAAGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References