Detailed information of TA system TA074455

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 345667..346178
• Replicon: plasmid pTs417
• Accession: NZ_CP020371
• Organism: Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: THSYN_RS30860
• Protein ID: WP_100922897.1
• Coordinates: 345912..346178 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: THSYN_RS30855
• Protein ID: WP_172965415.1
• Coordinates: 345667..345912 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THSYN_RS30845	340937..341161	-	225	WP_100922894.1	CopG family transcriptional regulator	-
THSYN_RS30850	341246..345481	-	4236	WP_100922895.1	BREX system serine/threonine kinase PglW	-
THSYN_RS30855	345667..345912	+	246	WP_172965415.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
THSYN_RS30860	345912..346178	+	267	WP_100922897.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
THSYN_RS30865	346159..347019	-	861	WP_100922898.1	transglutaminase family protein	-
THSYN_RS30870	347197..347874	-	678	WP_100922899.1	HAD hydrolase-like protein	-
THSYN_RS30875	348189..349274	-	1086	WP_100922900.1	phospholipase A	-
THSYN_RS30880	349424..349642	+	219	WP_100922901.1	DUF692 family protein	-
THSYN_RS30885	349615..349962	+	348	WP_100922902.1	hypothetical protein	-
THSYN_RS30890	350104..350286	-	183	WP_100922903.1	zf-HC2 domain-containing protein	-
THSYN_RS30895	350300..350668	-	369	WP_100922904.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..416864	416864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-75)

Antitoxin

• Antitoxin ParD (4-79)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9917.38 Da
• Isoelectric Point: 10.5112

>T74455 WP_100922897.1 NZ_CP020371:345912-346178 [Candidatus Thiodictyon syntrophicum]
MPRFVLTKAVKADLKAIGRYTQATWGRDHRTRYLTLLDAGFRALADNPLMGKDCDDIRPGYRKHQIEKHIAFYRQSGSGG
FALSPAAH

Nucleotide

• Length: 267 bp

>T74455 NZ_CP020371:345912-346178 [Candidatus Thiodictyon syntrophicum]
ATGCCCCGGTTTGTGCTGACCAAGGCAGTCAAGGCTGACTTGAAGGCCATCGGCCGCTACACCCAAGCCACTTGGGGCCG
TGACCATCGCACCCGTTATCTGACACTGTTGGACGCGGGCTTTCGTGCCTTGGCGGACAACCCTCTGATGGGGAAAGATT
GCGACGACATCCGCCCCGGCTACCGCAAGCACCAGATTGAAAAGCACATTGCTTTTTATCGTCAGAGCGGCAGCGGCGGG
TTTGCCCTCAGTCCGGCAGCGCACTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8828.77 Da
• Isoelectric Point: 5.5759

>AT74455 WP_172965415.1 NZ_CP020371:345667-345912 [Candidatus Thiodictyon syntrophicum]
ISLRNTSVTIGTHFEQFITRQIAQGRYGSASEAVRAGLRLLEEHELKLSTLRQALADGEASGRADYSLSGLLAELDSENT
H

Nucleotide

• Length: 246 bp

>AT74455 NZ_CP020371:345667-345912 [Candidatus Thiodictyon syntrophicum]
ATCTCCTTGCGGAACACTAGCGTTACCATTGGTACTCACTTCGAGCAATTCATCACCCGGCAGATCGCCCAAGGTCGCTA
CGGCTCGGCCAGTGAGGCGGTTAGAGCCGGTTTGCGGCTTCTGGAAGAACACGAACTGAAACTCTCTACCTTGCGTCAGG
CGCTCGCGGACGGTGAAGCCAGCGGCAGGGCGGACTATTCCCTGAGCGGGTTGCTGGCTGAACTTGACAGCGAAAATACG
CACTGA