Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 58126..59053 Replicon plasmid pTs417
Accession NZ_CP020371
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag THSYN_RS29590 Protein ID WP_100922702.1
Coordinates 58126..58752 (-) Length 209 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag THSYN_RS29595 Protein ID WP_100922703.1
Coordinates 58754..59053 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS29540 53315..53443 + 129 WP_100922695.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
THSYN_RS34485 53499..53702 + 204 WP_157818027.1 hypothetical protein -
THSYN_RS29545 53707..53938 + 232 Protein_56 hypothetical protein -
THSYN_RS29550 53954..54346 + 393 WP_100922696.1 site-specific integrase -
THSYN_RS29555 54752..55063 - 312 WP_100922697.1 type II toxin-antitoxin system RelE/ParE family toxin -
THSYN_RS29560 55063..55305 - 243 WP_100922698.1 type II toxin-antitoxin system ParD family antitoxin -
THSYN_RS29565 55511..55717 + 207 WP_100922699.1 hypothetical protein -
THSYN_RS29570 55842..55982 + 141 Protein_61 Fic family protein -
THSYN_RS29580 57102..57440 - 339 WP_100922700.1 BrnA antitoxin family protein -
THSYN_RS29585 57367..57636 - 270 WP_100922701.1 BrnT family toxin -
THSYN_RS29590 58126..58752 - 627 WP_100922702.1 GNAT family N-acetyltransferase Toxin
THSYN_RS29595 58754..59053 - 300 WP_100922703.1 DUF1778 domain-containing protein Antitoxin
THSYN_RS29600 59282..59567 + 286 Protein_66 hypothetical protein -
THSYN_RS29605 59571..59845 + 275 Protein_67 hypothetical protein -
THSYN_RS29610 59839..59991 + 153 Protein_68 type II toxin-antitoxin system ParD family antitoxin -
THSYN_RS29615 60105..60635 + 531 Protein_69 site-specific integrase -
THSYN_RS29620 60773..61258 + 486 WP_100922704.1 hypothetical protein -
THSYN_RS29625 62061..63458 - 1398 WP_100922705.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..416864 416864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-147)

Antitoxin

Vibrio phage ICP1, Orf50

(9-99)


Sequences

Toxin        


Download         Length: 209 a.a.        Molecular weight: 22898.07 Da        Isoelectric Point: 7.5162

>T74452 WP_100922702.1 NZ_CP020371:c58752-58126 [Candidatus Thiodictyon syntrophicum]
MPTVGTWTAPAPLAATHDLTIFESGEPALDHWLKTHARRNEGRGASRTYVVCNDDQVIGYYSLATGSVCSEQAPGRIRRN
MPNPIPVMLLGRLAIDLAWQRRGIGKALLRDAIFRTATVAQLVGVKALMVHALSESARRFYEVHGFDPSPTHPRTLFLPI
VLSSGELHRSTPHDRQVLRRDDFTAEDLKAVSAVEPSPQAAAFDDEIP

Download         Length: 627 bp

>T74452 NZ_CP020371:c58752-58126 [Candidatus Thiodictyon syntrophicum]
TTGCCAACGGTTGGCACCTGGACGGCGCCGGCGCCCCTCGCGGCGACGCATGACCTGACGATCTTTGAGAGCGGCGAGCC
GGCCCTCGACCACTGGCTGAAAACCCACGCCCGGCGCAACGAAGGACGCGGCGCGTCGCGCACCTATGTGGTGTGCAACG
ATGACCAGGTCATCGGCTACTACAGTCTGGCGACCGGTTCCGTATGCAGCGAACAGGCGCCCGGACGTATCCGGCGGAAT
ATGCCGAACCCGATTCCCGTCATGCTGCTTGGGCGCTTAGCGATTGATCTTGCGTGGCAGCGCCGCGGCATCGGCAAGGC
ACTGTTGCGCGATGCCATTTTCCGTACGGCCACGGTGGCGCAACTGGTGGGCGTCAAGGCGCTCATGGTCCATGCCCTGT
CCGAGTCGGCGCGGCGCTTTTATGAGGTTCATGGGTTTGATCCTTCACCGACGCACCCGCGCACCCTGTTTCTGCCGATC
GTCTTGTCGAGCGGTGAACTGCACCGCTCGACACCACACGACCGCCAGGTGTTGCGCCGGGATGATTTCACGGCAGAGGA
TCTGAAGGCCGTTTCGGCGGTCGAGCCTTCGCCGCAAGCCGCCGCTTTCGACGATGAAATACCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11043.46 Da        Isoelectric Point: 4.6050

>AT74452 WP_100922703.1 NZ_CP020371:c59053-58754 [Candidatus Thiodictyon syntrophicum]
MSSLESQETSGQTRDININIRAQRNQRDLIDQAARILGKTRSDFMLETACREAEDVLLDQRVFVLDAAAFAAFQALLDAP
PADNPRLRALLATKAPWET

Download         Length: 300 bp

>AT74452 NZ_CP020371:c59053-58754 [Candidatus Thiodictyon syntrophicum]
ATGTCATCCCTCGAATCCCAGGAGACCAGCGGCCAGACCCGGGACATCAACATCAACATTCGCGCCCAACGCAACCAACG
CGACCTGATCGACCAGGCGGCCCGGATTTTGGGCAAGACCCGCTCGGACTTCATGCTGGAGACGGCCTGCCGTGAGGCCG
AGGACGTGTTGCTGGACCAGCGCGTGTTCGTGCTGGACGCCGCGGCATTTGCGGCGTTTCAGGCGTTGCTGGACGCGCCG
CCCGCCGACAATCCCCGACTGCGTGCCTTGTTGGCAACCAAAGCGCCCTGGGAGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References