Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 54752..55305 Replicon plasmid pTs417
Accession NZ_CP020371
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag THSYN_RS29555 Protein ID WP_100922697.1
Coordinates 54752..55063 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag THSYN_RS29560 Protein ID WP_100922698.1
Coordinates 55063..55305 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS29520 50275..50841 - 567 WP_100922691.1 hypothetical protein -
THSYN_RS34475 51186..51815 - 630 WP_157818025.1 hypothetical protein -
THSYN_RS34480 51793..52263 - 471 WP_157818026.1 hypothetical protein -
THSYN_RS29525 52451..52681 - 231 WP_100922692.1 conjugal transfer protein TraD -
THSYN_RS29530 52827..53048 + 222 WP_100922693.1 MobA/MobL family protein -
THSYN_RS29535 53062..53235 - 174 WP_100922694.1 DUF190 domain-containing protein -
THSYN_RS29540 53315..53443 + 129 WP_100922695.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
THSYN_RS34485 53499..53702 + 204 WP_157818027.1 hypothetical protein -
THSYN_RS29545 53707..53938 + 232 Protein_56 hypothetical protein -
THSYN_RS29550 53954..54346 + 393 WP_100922696.1 site-specific integrase -
THSYN_RS29555 54752..55063 - 312 WP_100922697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
THSYN_RS29560 55063..55305 - 243 WP_100922698.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
THSYN_RS29565 55511..55717 + 207 WP_100922699.1 hypothetical protein -
THSYN_RS29570 55842..55982 + 141 Protein_61 Fic family protein -
THSYN_RS29580 57102..57440 - 339 WP_100922700.1 BrnA antitoxin family protein -
THSYN_RS29585 57367..57636 - 270 WP_100922701.1 BrnT family toxin -
THSYN_RS29590 58126..58752 - 627 WP_100922702.1 GNAT family N-acetyltransferase -
THSYN_RS29595 58754..59053 - 300 WP_100922703.1 DUF1778 domain-containing protein -
THSYN_RS29600 59282..59567 + 286 Protein_66 hypothetical protein -
THSYN_RS29605 59571..59845 + 275 Protein_67 hypothetical protein -
THSYN_RS29610 59839..59991 + 153 Protein_68 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..416864 416864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11692.25 Da        Isoelectric Point: 9.5224

>T74451 WP_100922697.1 NZ_CP020371:c55063-54752 [Candidatus Thiodictyon syntrophicum]
MPRFVLTKAANADLKGIGRYTQATWGRDQRTRYLTLLDAGFRALADNPLMGKDCDDIRPGYRKHQIEKHIAFYRQSGSGQ
IEIVRVLHERMDLEANLSASGDN

Download         Length: 312 bp

>T74451 NZ_CP020371:c55063-54752 [Candidatus Thiodictyon syntrophicum]
ATGCCCCGGTTTGTGCTGACCAAGGCGGCCAATGCTGACTTGAAGGGCATCGGCCGCTACACCCAAGCCACTTGGGGCCG
TGACCAGCGCACCCGTTATCTGACGTTGTTGGACGCAGGCTTTCGTGCCTTGGCGGACAACCCGCTGATGGGGAAAGATT
GCGACGACATCCGTCCCGGCTACCGCAAGCACCAGATTGAAAAGCACATTGCTTTTTATCGTCAGAGTGGCAGCGGTCAG
ATTGAGATTGTTCGCGTCTTGCACGAGCGCATGGACCTGGAGGCCAACCTTTCAGCGTCCGGCGACAACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8691.60 Da        Isoelectric Point: 5.0228

>AT74451 WP_100922698.1 NZ_CP020371:c55305-55063 [Candidatus Thiodictyon syntrophicum]
MQKNTSVTIGTHFEQFITQQIAQGRYGSASEAVRAGLRLLEEHELKLSTLRQALADGEASGRADYSLSGLLAELDSESTH

Download         Length: 243 bp

>AT74451 NZ_CP020371:c55305-55063 [Candidatus Thiodictyon syntrophicum]
ATGCAGAAAAACACTAGCGTGACCATTGGTACTCACTTCGAGCAATTCATCACCCAGCAGATCGCCCAAGGTCGCTACGG
CTCGGCCAGTGAGGCGGTTAGAGCCGGTTTGCGGCTTCTGGAAGAACACGAACTGAAGCTGTCTACCTTGCGTCAGGCGC
TCGCGGACGGTGAAGCCAGCGGCAGGGCGGACTATTCCCTGAGCGGGTTGCTGGCCGAACTTGACAGCGAAAGTACGCAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References