Detailed information of TA system TA074450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 6260863..6261502
• Replicon: chromosome
• Accession: NZ_CP020370
• Organism: Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THSYN_RS26850
• Protein ID: WP_100921834.1
• Coordinates: 6261095..6261502 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: THSYN_RS26845
• Protein ID: WP_100921833.1
• Coordinates: 6260863..6261093 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THSYN_RS26825	6256740..6257849	+	1110	WP_100921829.1	DegT/DnrJ/EryC1/StrS family aminotransferase	-
THSYN_RS26830	6257842..6258513	+	672	WP_100921830.1	acetyltransferase	-
THSYN_RS26835	6258526..6259323	+	798	WP_100921831.1	cephalosporin hydroxylase family protein	-
THSYN_RS26840	6259265..6260158	-	894	WP_100921832.1	glycosyltransferase family 2 protein	-
THSYN_RS26845	6260863..6261093	+	231	WP_100921833.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
THSYN_RS26850	6261095..6261502	+	408	WP_100921834.1	PIN domain-containing protein	Toxin
THSYN_RS26855	6261644..6262309	+	666	WP_100921835.1	DUF3782 domain-containing protein	-
THSYN_RS34385	6262334..6262696	+	363	WP_157817962.1	type II toxin-antitoxin system VapC family toxin	-
THSYN_RS26865	6263233..6265056	+	1824	WP_100921837.1	translational GTPase TypA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	ddhA	6251040..6261502	10462

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-40)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14703.96 Da
• Isoelectric Point: 6.7297

>T74450 WP_100921834.1 NZ_CP020370:6261095-6261502 [Candidatus Thiodictyon syntrophicum]
MRYLMDTNTFIAAMKGVAAVRDKLEHTPLSDLVLSPVVLGELELGIEKSAHREKNAARLAGVVARIELLPLDARVSRHYA
TIRADLERKGTPIGANDYWIAAQGLAFGAVVVTDNEAEFTRVPGLAVENWLRAAP

Nucleotide

• Length: 408 bp

>T74450 NZ_CP020370:6261095-6261502 [Candidatus Thiodictyon syntrophicum]
ATGCGCTACCTGATGGACACCAACACCTTCATCGCCGCCATGAAAGGCGTCGCAGCTGTGCGCGACAAACTTGAGCACAC
CCCGCTGAGCGACCTGGTGCTTTCTCCCGTGGTGCTTGGCGAACTCGAACTCGGTATCGAAAAGAGTGCGCATCGCGAAA
AGAATGCCGCCCGTTTGGCCGGCGTCGTGGCAAGGATCGAGTTGCTGCCGCTCGATGCCAGGGTTAGCCGGCATTACGCC
ACCATCCGCGCCGACTTGGAGCGTAAGGGCACTCCGATCGGCGCCAACGATTACTGGATCGCTGCGCAGGGTCTCGCCTT
TGGCGCAGTGGTCGTTACAGACAATGAAGCCGAATTCACCCGCGTCCCGGGTCTGGCGGTCGAGAACTGGCTCCGCGCCG
CGCCTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8224.55 Da
• Isoelectric Point: 4.6721

>AT74450 WP_100921833.1 NZ_CP020370:6260863-6261093 [Candidatus Thiodictyon syntrophicum]
MRSVQVVEAKAKFSALLAAVEAGETVAIMRRGRVVAQLVPDSPRMAADPFRPLWAEQDDIDLVRPADLAAEPVTPI

Nucleotide

• Length: 231 bp

>AT74450 NZ_CP020370:6260863-6261093 [Candidatus Thiodictyon syntrophicum]
ATGCGCAGCGTACAAGTCGTAGAAGCAAAAGCAAAATTTTCTGCCCTTTTGGCGGCGGTCGAAGCCGGCGAAACGGTCGC
GATCATGCGGCGCGGCCGGGTCGTCGCGCAGCTTGTCCCGGATTCCCCACGCATGGCCGCCGACCCATTCAGGCCCCTCT
GGGCCGAGCAAGACGACATCGACCTGGTCCGGCCGGCGGATCTGGCCGCCGAACCCGTCACGCCGATCTAG