Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5417205..5418373 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag THSYN_RS22935 Protein ID WP_100921181.1
Coordinates 5417576..5418373 (+) Length 266 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag THSYN_RS22930 Protein ID WP_100921180.1
Coordinates 5417205..5417561 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS22915 5412920..5414365 + 1446 WP_100921177.1 amidohydrolase family protein -
THSYN_RS22920 5414504..5416369 + 1866 WP_100921178.1 phosphoenolpyruvate carboxykinase (GTP) -
THSYN_RS22925 5416471..5417049 + 579 WP_100921179.1 hypothetical protein -
THSYN_RS22930 5417205..5417561 + 357 WP_100921180.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
THSYN_RS22935 5417576..5418373 + 798 WP_100921181.1 RES family NAD+ phosphorylase Toxin
THSYN_RS22940 5419150..5419587 + 438 WP_172965323.1 CBS domain-containing protein -
THSYN_RS22945 5419751..5420479 - 729 WP_157817871.1 HIRAN domain-containing protein -
THSYN_RS22950 5420485..5421399 - 915 WP_100921184.1 phosphatidylinositol kinase -
THSYN_RS22955 5421485..5422621 - 1137 WP_157817872.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(76-224)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(10-63)


Sequences

Toxin        


Download         Length: 266 a.a.        Molecular weight: 29277.49 Da        Isoelectric Point: 7.7041

>T74448 WP_100921181.1 NZ_CP020370:5417576-5418373 [Candidatus Thiodictyon syntrophicum]
MHAFPGTPQTVADGTLDLWNLCHTGLQPFPLEGELLRLVESQEQVATTSLVDDLAEQSLLEDLLEPSKPPRRPGTQRLHY
LLATPFRYPPLPHGSRFGSRLEPGIFYAALGEAATLAECAYYRLVFWSAMCTPPPSGRLLTQHTLFRARYRGTRGLRLQA
PPCAAHEPVLRHPCDYGPTQRLGRALRDAGVELIEYRSARDPASGLNLALFDPAALASRRPLDPEPWLCETRADRVIFSG
PRGRTVQGFHLADFTVAGRLPLPAG

Download         Length: 798 bp

>T74448 NZ_CP020370:5417576-5418373 [Candidatus Thiodictyon syntrophicum]
ATGCACGCCTTCCCAGGGACGCCGCAAACCGTGGCCGATGGCACCCTTGACCTCTGGAACCTCTGCCATACCGGGCTCCA
ACCGTTCCCCCTGGAGGGTGAGTTGCTGCGCCTCGTCGAGAGTCAGGAACAGGTGGCAACCACCAGCCTGGTCGACGACC
TGGCCGAGCAATCACTGCTCGAAGACCTCCTGGAGCCCAGCAAGCCGCCGCGGCGCCCCGGCACCCAGCGGCTGCACTAT
CTGCTCGCGACCCCCTTTCGCTATCCGCCCCTGCCGCACGGATCGCGCTTCGGCTCCCGCCTTGAGCCCGGGATCTTCTA
CGCCGCCTTGGGGGAAGCCGCCACGCTTGCCGAGTGCGCCTACTACCGGTTGGTGTTCTGGAGCGCCATGTGCACGCCCC
CGCCATCCGGGCGTCTGCTGACCCAGCACACACTCTTTCGTGCCCGTTACCGCGGCACCCGGGGCCTGCGGCTTCAGGCC
CCGCCCTGTGCGGCGCACGAACCGGTCCTGCGCCACCCCTGCGACTATGGTCCCACCCAGCGCCTCGGTCGCGCCCTGCG
CGACGCCGGTGTCGAGTTGATCGAATACCGCTCGGCGCGCGACCCGGCCAGCGGCCTCAACCTGGCCCTGTTCGACCCCG
CTGCGCTCGCCAGCCGTCGTCCCCTCGATCCAGAACCCTGGCTCTGTGAGACCCGCGCCGACCGGGTAATCTTCTCCGGC
CCCCGGGGTCGCACCGTACAGGGCTTTCACCTTGCCGACTTCACGGTCGCGGGGCGACTGCCGCTCCCGGCGGGCTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12784.72 Da        Isoelectric Point: 9.6868

>AT74448 WP_100921180.1 NZ_CP020370:5417205-5417561 [Candidatus Thiodictyon syntrophicum]
MNTVAERIPDATAVLSKALLNAGRLLGLSQTDLGVIVGKDRSSIARGLDPQSKSGELALLLIRCYRSLYVLVGGEGADLR
HWMHTENRDTGGVPAQQVRSVQGLTRVLEYLDAMRGRV

Download         Length: 357 bp

>AT74448 NZ_CP020370:5417205-5417561 [Candidatus Thiodictyon syntrophicum]
ATGAATACCGTCGCCGAGCGCATCCCTGATGCAACAGCGGTGTTGAGCAAGGCCCTGCTCAACGCGGGGCGCCTGCTCGG
GCTGTCCCAGACAGACCTCGGCGTCATCGTGGGCAAGGACCGTAGCTCCATCGCCCGCGGCCTGGACCCCCAGAGCAAGT
CCGGCGAACTGGCCCTGCTCCTGATCCGCTGCTACCGCAGCCTCTATGTCCTGGTGGGCGGTGAGGGCGCAGACCTGCGC
CACTGGATGCACACCGAGAACCGGGACACGGGCGGGGTACCGGCGCAGCAAGTCCGTTCAGTGCAGGGTCTGACCCGGGT
ACTGGAGTACCTGGACGCGATGCGCGGACGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References