Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5213316..5213961 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag THSYN_RS21960 Protein ID WP_100921004.1
Coordinates 5213316..5213732 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag THSYN_RS21965 Protein ID WP_100921005.1
Coordinates 5213716..5213961 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS21930 5210029..5210217 - 189 WP_100920999.1 hypothetical protein -
THSYN_RS21935 5210301..5210867 + 567 WP_100921000.1 Uma2 family endonuclease -
THSYN_RS21940 5211476..5211778 + 303 WP_100921001.1 hypothetical protein -
THSYN_RS21945 5211775..5212068 + 294 WP_100921002.1 BrnT family toxin -
THSYN_RS21950 5212052..5212243 + 192 Protein_4373 hypothetical protein -
THSYN_RS21955 5212457..5213284 - 828 WP_100921003.1 glutamate racemase -
THSYN_RS21960 5213316..5213732 - 417 WP_100921004.1 type II toxin-antitoxin system VapC family toxin Toxin
THSYN_RS21965 5213716..5213961 - 246 WP_100921005.1 antitoxin Antitoxin
THSYN_RS21970 5214318..5215157 - 840 WP_100921006.1 exodeoxyribonuclease III -
THSYN_RS21975 5215443..5216606 - 1164 WP_100921007.1 lipid-A-disaccharide synthase -
THSYN_RS21980 5216606..5217376 - 771 WP_100921008.1 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase -
THSYN_RS21985 5217373..5217900 - 528 WP_100921009.1 3-hydroxyacyl-ACP dehydratase FabZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(8-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15211.50 Da        Isoelectric Point: 10.1960

>T74447 WP_100921004.1 NZ_CP020370:c5213732-5213316 [Candidatus Thiodictyon syntrophicum]
MLWMLDTNTSSFVIRRRPPSVKARFDAVGHGNLAISVVVLAELWFGAELHPTRGTAIRHDIDDFRRRLRVLPWTESAAAA
YAGVRAVLHGQGTPIGNMDLLIAAHALSLDAVLVTNNTREFKRVPGLRCEDWVSSPSA

Download         Length: 417 bp

>T74447 NZ_CP020370:c5213732-5213316 [Candidatus Thiodictyon syntrophicum]
ATGCTTTGGATGCTTGACACCAATACCAGCAGCTTCGTGATCCGCCGCCGCCCGCCAAGTGTGAAGGCCAGGTTCGACGC
GGTGGGCCATGGCAATCTCGCCATCTCGGTCGTCGTGTTGGCCGAACTGTGGTTCGGCGCCGAACTCCATCCGACCCGCG
GCACCGCGATTCGGCACGACATCGACGATTTTCGTCGCCGTCTCCGGGTGCTGCCCTGGACCGAGTCGGCCGCCGCCGCC
TATGCCGGTGTCCGTGCGGTGCTGCATGGGCAGGGGACACCGATCGGTAACATGGACCTGCTGATTGCGGCCCATGCGTT
GTCGCTGGACGCCGTGTTGGTCACGAACAACACCCGGGAGTTCAAGCGCGTACCTGGGTTGCGGTGCGAGGACTGGGTGT
CCTCGCCGAGCGCCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9038.13 Da        Isoelectric Point: 4.8053

>AT74447 WP_100921005.1 NZ_CP020370:c5213961-5213716 [Candidatus Thiodictyon syntrophicum]
VHKTAKLFVNGRSQAVRLPAEFRFEGKEVYIERAGDAVILRPKPVGWDDFFAGPSATPDEFLADRDDAPPQERDCLHALD
A

Download         Length: 246 bp

>AT74447 NZ_CP020370:c5213961-5213716 [Candidatus Thiodictyon syntrophicum]
GTGCACAAGACCGCAAAGCTCTTCGTCAACGGCCGCAGCCAGGCGGTGCGGCTGCCCGCCGAGTTCCGCTTCGAGGGCAA
AGAGGTCTATATCGAGCGCGCGGGCGATGCCGTGATCCTGCGTCCGAAGCCCGTCGGCTGGGACGATTTCTTCGCCGGTC
CGTCCGCGACGCCGGACGAGTTTCTCGCCGATCGCGATGATGCGCCGCCCCAAGAGCGGGACTGCCTCCATGCTTTGGAT
GCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References