Detailed information of TA system TA074446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 5163955..5164499
• Replicon: chromosome
• Accession: NZ_CP020370
• Organism: Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: THSYN_RS21750
• Protein ID: WP_100920972.1
• Coordinates: 5163955..5164257 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: THSYN_RS21755
• Protein ID: WP_100920973.1
• Coordinates: 5164257..5164499 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THSYN_RS21740	5159873..5163130	-	3258	WP_100920970.1	ATP-binding protein	-
THSYN_RS21745	5163028..5163792	-	765	WP_100920971.1	hypothetical protein	-
THSYN_RS21750	5163955..5164257	-	303	WP_100920972.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
THSYN_RS21755	5164257..5164499	-	243	WP_100920973.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
THSYN_RS21760	5164690..5165232	-	543	WP_157817848.1	hypothetical protein	-
THSYN_RS21765	5165247..5166455	-	1209	WP_100920975.1	DUF1343 domain-containing protein	-
THSYN_RS21770	5166801..5168105	+	1305	WP_100919380.1	transposase	-
THSYN_RS21775	5168368..5168679	+	312	WP_100920976.1	pyrimidine/purine nucleoside phosphorylase	-
THSYN_RS21780	5168717..5168980	-	264	WP_100920977.1	ferredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11310.94 Da
• Isoelectric Point: 9.1378

>T74446 WP_100920972.1 NZ_CP020370:c5164257-5163955 [Candidatus Thiodictyon syntrophicum]
MPRFVLTKAAKDDLKSIGRYTQATWGPDQRNRYLRLLDAGFHTLADNPLMGTDCGDIRPGYRKHRVGKHLVFCRQSGTDE
IEIVRVLHQGMDVPASMSDP

Nucleotide

• Length: 303 bp

>T74446 NZ_CP020370:c5164257-5163955 [Candidatus Thiodictyon syntrophicum]
ATGCCCCGGTTCGTGCTGACCAAGGCAGCCAAGGACGATTTGAAGTCCATCGGCCGCTACACGCAAGCCACCTGGGGTCC
TGACCAGCGCAACCGCTATCTGAGGTTGCTGGACGCGGGCTTTCATACGCTGGCGGATAATCCCCTGATGGGCACTGACT
GCGGCGACATCCGCCCCGGCTATCGCAAGCACCGGGTTGGCAAGCATCTCGTGTTTTGTCGTCAGAGCGGCACCGATGAG
ATTGAGATTGTTCGTGTCCTGCACCAGGGCATGGACGTACCTGCGTCCATGTCCGATCCCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8836.86 Da
• Isoelectric Point: 5.5976

>AT74446 WP_100920973.1 NZ_CP020370:c5164499-5164257 [Candidatus Thiodictyon syntrophicum]
MQKNTSVILGDHFEQFLAQQIAQGRYGSASEAIRAGLRLLEEHETRVAALRQALKEGEASGRADYSLQGLIEELDRVGTH

Nucleotide

• Length: 243 bp

>AT74446 NZ_CP020370:c5164499-5164257 [Candidatus Thiodictyon syntrophicum]
ATGCAGAAGAACACCAGCGTGATCCTTGGCGACCACTTCGAGCAATTCCTTGCCCAGCAGATTGCCCAGGGCCGTTACGG
TTCGGCCAGCGAGGCGATCCGTGCCGGGTTGCGGCTTCTGGAAGAGCATGAAACACGCGTTGCCGCCCTGCGTCAGGCGC
TCAAGGAGGGCGAGGCAAGCGGCCGGGCCGACTATTCCCTGCAAGGTCTGATCGAGGAACTCGACCGCGTCGGTACGCAC
TGA