Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 5117535..5118106 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag THSYN_RS21560 Protein ID WP_172965383.1
Coordinates 5117535..5117873 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag THSYN_RS21565 Protein ID WP_100920939.1
Coordinates 5117873..5118106 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS21535 5113780..5113962 - 183 WP_100920934.1 hypothetical protein -
THSYN_RS21540 5114168..5115688 + 1521 WP_100920935.1 exopolyphosphatase -
THSYN_RS21545 5115835..5116020 + 186 WP_100920936.1 hypothetical protein -
THSYN_RS21550 5116878..5117117 + 240 WP_100922533.1 DUF4160 domain-containing protein -
THSYN_RS21555 5117089..5117352 + 264 WP_100920937.1 DUF2442 domain-containing protein -
THSYN_RS21560 5117535..5117873 - 339 WP_172965383.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
THSYN_RS21565 5117873..5118106 - 234 WP_100920939.1 ribbon-helix-helix domain-containing protein Antitoxin
THSYN_RS21570 5118430..5119908 + 1479 WP_100920940.1 nitrogenase iron-molybdenum cofactor biosynthesis protein NifE -
THSYN_RS21575 5119901..5121289 + 1389 WP_100920941.1 nitrogenase iron-molybdenum cofactor biosynthesis protein NifN -
THSYN_RS21580 5121467..5121952 + 486 WP_100920942.1 nitrogen fixation protein NifX -
THSYN_RS21585 5122321..5122794 + 474 WP_100920943.1 NifX-associated nitrogen fixation protein -
THSYN_RS21590 5122808..5123023 + 216 WP_100920944.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5116827..5125996 9169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12063.92 Da        Isoelectric Point: 7.7956

>T74445 WP_172965383.1 NZ_CP020370:c5117873-5117535 [Candidatus Thiodictyon syntrophicum]
IRQGDLWWADLGEPVGSEPGYRRPVVIVQCDAFNRSRLATVVCVPLTSNLKWADAPGNVLLESRGAGLAKDSVANVSQLL
TIDRGTLTERIGRLAKPQLDAILAGIDMVLGR

Download         Length: 339 bp

>T74445 NZ_CP020370:c5117873-5117535 [Candidatus Thiodictyon syntrophicum]
ATCCGGCAGGGTGATCTCTGGTGGGCAGACCTGGGCGAACCGGTCGGCTCCGAACCGGGTTATCGGCGCCCCGTTGTCAT
CGTCCAGTGCGATGCGTTCAACCGCAGCCGGCTCGCGACCGTCGTTTGCGTCCCGCTGACCAGCAACCTCAAGTGGGCCG
ACGCCCCAGGTAATGTCCTGCTTGAGTCACGCGGAGCCGGGTTGGCCAAGGACTCGGTCGCGAATGTCTCCCAACTCCTG
ACCATTGACCGCGGCACCTTGACCGAGCGGATCGGTAGGCTCGCAAAGCCGCAACTCGACGCGATCCTGGCGGGTATCGA
CATGGTGCTGGGGCGCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8769.91 Da        Isoelectric Point: 5.1035

>AT74445 WP_100920939.1 NZ_CP020370:c5118106-5117873 [Candidatus Thiodictyon syntrophicum]
MKTAISVPDDVFGEAENLAARLRISRSDLYARALKEFLERHADQVTTTLDTLCSDIDSKPDEFLVRSARKVLRSTEW

Download         Length: 234 bp

>AT74445 NZ_CP020370:c5118106-5117873 [Candidatus Thiodictyon syntrophicum]
ATGAAAACAGCTATCTCGGTTCCAGATGACGTGTTCGGTGAGGCCGAAAACCTCGCCGCCCGCCTGCGGATTTCCCGTAG
TGATCTCTATGCGCGGGCGCTCAAGGAATTCCTGGAGCGACACGCTGACCAAGTGACAACGACCCTCGACACCCTCTGCA
GTGACATCGACAGTAAGCCGGACGAATTCCTGGTCCGGTCGGCCCGCAAGGTGCTTCGGAGCACCGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References