Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3627364..3627941 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag THSYN_RS15160 Protein ID WP_100922443.1
Coordinates 3627609..3627941 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag THSYN_RS15155 Protein ID WP_100919883.1
Coordinates 3627364..3627606 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS15135 3622516..3622704 - 189 WP_100919880.1 hypothetical protein -
THSYN_RS15140 3623375..3624517 + 1143 WP_157817699.1 hypothetical protein -
THSYN_RS15150 3625177..3626850 + 1674 WP_100919882.1 ATP-binding protein -
THSYN_RS15155 3627364..3627606 + 243 WP_100919883.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
THSYN_RS15160 3627609..3627941 + 333 WP_100922443.1 endoribonuclease MazF Toxin
THSYN_RS15165 3627956..3628864 - 909 WP_100922444.1 CHAP domain-containing protein -
THSYN_RS15170 3628874..3628960 - 87 Protein_3029 type II toxin-antitoxin system PemK/MazF family toxin -
THSYN_RS15175 3628966..3629217 - 252 WP_100919884.1 antitoxin -
THSYN_RS15180 3629696..3630634 + 939 WP_100919885.1 patatin-like phospholipase family protein -
THSYN_RS15185 3630711..3631298 - 588 WP_100919886.1 Uma2 family endonuclease -
THSYN_RS15190 3631392..3632135 - 744 WP_100919887.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11891.84 Da        Isoelectric Point: 8.5160

>T74443 WP_100922443.1 NZ_CP020370:3627609-3627941 [Candidatus Thiodictyon syntrophicum]
VPRYVPDAGDIVWLHFDPQAGHEQAGHRPALVISPAAYNGKTDLMLCCPMTTHIKGYPFEVPIVGDRPGAVLADQVKSLD
WVARKALRKGRVTTAELAQVQGKILALIGP

Download         Length: 333 bp

>T74443 NZ_CP020370:3627609-3627941 [Candidatus Thiodictyon syntrophicum]
GTGCCGCGGTATGTGCCGGACGCCGGCGACATCGTGTGGCTGCATTTCGACCCTCAGGCCGGTCATGAGCAGGCCGGTCA
CCGACCAGCCCTGGTCATCAGCCCGGCGGCCTACAACGGTAAGACCGATTTGATGCTGTGTTGTCCGATGACGACGCACA
TCAAAGGCTATCCGTTCGAGGTCCCCATTGTCGGCGACCGCCCCGGCGCGGTGCTCGCCGATCAGGTGAAGAGCCTGGAT
TGGGTGGCCCGCAAGGCGCTCCGCAAGGGTCGCGTCACCACCGCTGAATTGGCGCAAGTGCAGGGAAAGATCCTGGCCCT
GATCGGCCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8735.00 Da        Isoelectric Point: 5.1023

>AT74443 WP_100919883.1 NZ_CP020370:3627364-3627606 [Candidatus Thiodictyon syntrophicum]
MRVVVKKWGNSAAVRIPVGVMAAARVSLDEEVDIREEGGRILIEPIRSHAYDLAELLSGITPENRHAEVDFGTPVGREAL

Download         Length: 243 bp

>AT74443 NZ_CP020370:3627364-3627606 [Candidatus Thiodictyon syntrophicum]
ATGCGCGTCGTAGTGAAGAAATGGGGCAACAGCGCGGCCGTGCGCATCCCGGTCGGGGTCATGGCCGCCGCGCGGGTGAG
CCTGGATGAGGAGGTGGACATTCGCGAGGAAGGCGGGCGGATCCTGATCGAGCCGATCCGGTCGCACGCCTACGACCTGG
CGGAACTGCTGTCCGGGATCACGCCGGAGAATCGGCACGCCGAGGTGGATTTCGGTACCCCGGTCGGGCGTGAGGCGCTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References