Detailed information of TA system TA074439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 177259..177887
• Replicon: chromosome
• Accession: NZ_CP020370
• Organism: Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THSYN_RS00765
• Protein ID: WP_100917449.1
• Coordinates: 177501..177887 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: THSYN_RS00760
• Protein ID: WP_100917448.1
• Coordinates: 177259..177504 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THSYN_RS00750	173048..176122	-	3075	WP_100917446.1	CHAT domain-containing protein	-
THSYN_RS00755	176160..176951	-	792	WP_100917447.1	caspase family protein	-
THSYN_RS00760	177259..177504	+	246	WP_100917448.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
THSYN_RS00765	177501..177887	+	387	WP_100917449.1	type II toxin-antitoxin system VapC family toxin	Toxin
THSYN_RS00770	178092..179189	+	1098	Protein_155	cysteine desulfurase	-
THSYN_RS00775	179258..182206	-	2949	WP_100917450.1	DEAD/DEAH box helicase family protein	-
THSYN_RS00780	182191..182802	-	612	WP_100917451.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (8-127)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-43)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14573.76 Da
• Isoelectric Point: 6.3309

>T74439 WP_100917449.1 NZ_CP020370:177501-177887 [Candidatus Thiodictyon syntrophicum]
VTGRSRLLLDTHAFLWWKLDDPQLKMDARIAITQAELVFVSAASAWEAAIKARLGKLDLTVDFAQGVKESGFERLPIGFQ
HAAETRNLPDHHRDPFDRMLIAQARVERLVVVTHDPLFEPYGLDLIWT

Nucleotide

• Length: 387 bp

>T74439 NZ_CP020370:177501-177887 [Candidatus Thiodictyon syntrophicum]
GTGACGGGCCGGTCGCGGCTGTTGCTGGACACCCATGCCTTCCTCTGGTGGAAGCTGGATGATCCGCAGTTGAAGATGGA
CGCTCGCATCGCGATCACCCAGGCCGAACTGGTGTTCGTCAGTGCCGCTTCCGCCTGGGAGGCCGCCATCAAGGCGCGCT
TGGGCAAACTGGACCTGACGGTCGACTTTGCGCAAGGCGTCAAGGAGAGCGGCTTCGAGCGCCTGCCCATCGGCTTTCAA
CACGCCGCCGAGACCCGCAACCTGCCGGACCACCACCGCGACCCCTTCGACCGGATGCTGATTGCACAGGCACGCGTCGA
GCGTTTGGTGGTGGTAACCCATGATCCACTGTTCGAGCCCTATGGGCTGGATTTGATCTGGACCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8758.03 Da
• Isoelectric Point: 4.7247

>AT74439 WP_100917448.1 NZ_CP020370:177259-177504 [Candidatus Thiodictyon syntrophicum]
MSETVLNLYQAKTLLSELVDRAAGGEEIVIAKAGRPLAKLVPLCSPRDRRSPGGWQGKVRVSEDFDAPLPPDLIDAFEGQ
P

Nucleotide

• Length: 246 bp

>AT74439 NZ_CP020370:177259-177504 [Candidatus Thiodictyon syntrophicum]
ATGTCGGAAACCGTCCTCAATCTCTATCAAGCCAAGACCCTGCTCTCTGAGCTGGTCGATCGTGCCGCCGGCGGGGAGGA
GATCGTAATCGCCAAGGCTGGCCGGCCCCTCGCCAAGCTGGTGCCCCTGTGCAGCCCGCGTGACCGGCGCAGCCCCGGCG
GCTGGCAGGGGAAGGTCCGGGTCAGCGAGGACTTCGACGCCCCGCTGCCGCCGGACCTGATCGACGCCTTCGAGGGTCAG
CCGTGA