Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 147984..148649 Replicon chromosome
Accession NZ_CP020370
Organism Candidatus Thiodictyon syntrophicum strain Cad16T

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag THSYN_RS00630 Protein ID WP_100917430.1
Coordinates 147984..148403 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag THSYN_RS00635 Protein ID WP_100917431.1
Coordinates 148416..148649 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THSYN_RS00610 145882..146412 - 531 WP_157817376.1 toll/interleukin-1 receptor domain-containing protein -
THSYN_RS00615 146739..146939 - 201 WP_100917427.1 hypothetical protein -
THSYN_RS33290 146976..147158 - 183 WP_157817377.1 PIN domain nuclease -
THSYN_RS33295 147139..147387 - 249 WP_157817378.1 hypothetical protein -
THSYN_RS00625 147611..147931 - 321 WP_157817379.1 hypothetical protein -
THSYN_RS00630 147984..148403 - 420 WP_100917430.1 type II toxin-antitoxin system VapC family toxin Toxin
THSYN_RS00635 148416..148649 - 234 WP_100917431.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
THSYN_RS00640 148907..149254 - 348 WP_100917432.1 helix-turn-helix domain-containing protein -
THSYN_RS00645 149251..149616 - 366 WP_100917433.1 hypothetical protein -
THSYN_RS00650 149735..152032 - 2298 WP_100917434.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-126)

Antitoxin

SpoVT-AbrB domain

(10-51)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15150.43 Da        Isoelectric Point: 7.2460

>T74438 WP_100917430.1 NZ_CP020370:c148403-147984 [Candidatus Thiodictyon syntrophicum]
MPKPAYLLDTNIVSDLVRRPAGSIRDCIAARGEERVCTSIVVAAELRFGAAKKGSQRLTAQLKTVLTALDILPFDEPADR
RYGEIRAALERAGTPIGTNDLLIAAHALAHGLILVTANEDEFRRVPGLVVENWLNHEGR

Download         Length: 420 bp

>T74438 NZ_CP020370:c148403-147984 [Candidatus Thiodictyon syntrophicum]
ATGCCGAAGCCCGCGTATCTGCTCGACACCAACATCGTCTCCGATCTCGTGCGTCGGCCCGCGGGGAGCATCCGCGACTG
CATCGCCGCGCGCGGCGAGGAACGGGTCTGCACCAGCATCGTCGTCGCCGCGGAGTTGCGTTTCGGCGCGGCGAAGAAGG
GCTCGCAGCGGTTGACCGCCCAACTGAAGACCGTGCTGACGGCCCTGGACATCCTGCCCTTCGACGAGCCCGCGGATCGC
CGCTACGGCGAGATCCGAGCGGCGCTCGAACGCGCGGGCACGCCGATCGGCACCAACGACCTGCTCATCGCGGCCCACGC
CCTTGCACACGGCCTGATCCTGGTCACCGCCAACGAGGACGAGTTCCGCCGCGTGCCGGGGCTGGTGGTCGAGAACTGGT
TGAATCACGAAGGCCGGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.82 Da        Isoelectric Point: 4.5219

>AT74438 WP_100917431.1 NZ_CP020370:c148649-148416 [Candidatus Thiodictyon syntrophicum]
MHASRRATLFINGSNQAIRIPRDFELPGKEALIHKEGDRLIIEPVPPPRLLAVLATLDPIDDTFPDIQDPAPEPVDL

Download         Length: 234 bp

>AT74438 NZ_CP020370:c148649-148416 [Candidatus Thiodictyon syntrophicum]
ATGCACGCATCCCGCCGCGCTACCCTCTTCATCAATGGCAGCAATCAAGCGATTCGCATCCCGCGGGACTTTGAACTGCC
CGGCAAGGAAGCCCTGATCCACAAGGAAGGCGACCGCCTCATCATCGAGCCAGTGCCCCCGCCGAGACTGCTCGCGGTGC
TGGCAACCCTCGACCCCATCGACGACACCTTCCCCGACATCCAGGACCCGGCGCCGGAGCCGGTCGATCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References