Detailed information of TA system TA074407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1779676..1780179
• Replicon: chromosome
• Accession: NZ_CP020364
• Organism: Sulfolobus acidocaldarius strain DG1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B6A19_RS11965
• Protein ID: WP_162465564.1
• Coordinates: 1780024..1780179 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: B6A19_RS09670
• Protein ID: WP_011278775.1
• Coordinates: 1779676..1779918 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A19_RS09650	1775188..1776675	+	1488	WP_230949672.1	AMP-binding protein	-
B6A19_RS09655	1776662..1777780	+	1119	WP_011278772.1	arabinonate dehydratase	-
B6A19_RS09660	1777782..1778942	+	1161	WP_011278773.1	thiolase family protein	-
B6A19_RS09665	1778935..1779279	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
B6A19_RS09670	1779676..1779918	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
B6A19_RS11965	1780024..1780179	+	156	WP_162465564.1	hypothetical protein	Toxin
B6A19_RS09675	1780638..1781963	+	1326	WP_015385888.1	APC family permease	-
B6A19_RS09680	1782122..1784368	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T74407 WP_162465564.1 NZ_CP020364:1780024-1780179 [Sulfolobus acidocaldarius]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T74407 NZ_CP020364:1780024-1780179 [Sulfolobus acidocaldarius]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT74407 WP_011278775.1 NZ_CP020364:1779676-1779918 [Sulfolobus acidocaldarius]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT74407 NZ_CP020364:1779676-1779918 [Sulfolobus acidocaldarius]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0