Detailed information of TA system TA074406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1766098..1766704
• Replicon: chromosome
• Accession: NZ_CP020364
• Organism: Sulfolobus acidocaldarius strain DG1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1ITB5
• Locus tag: B6A19_RS09590
• Protein ID: WP_011278759.1
• Coordinates: 1766098..1766493 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7B9
• Locus tag: B6A19_RS09595
• Protein ID: WP_011278760.1
• Coordinates: 1766477..1766704 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A19_RS09565	1762450..1762980	+	531	WP_011278754.1	PaREP1 family protein	-
B6A19_RS09570	1763589..1764266	-	678	WP_011278755.1	hypothetical protein	-
B6A19_RS12175	1764865..1764990	-	126	WP_257719735.1	hypothetical protein	-
B6A19_RS09580	1765229..1765477	+	249	WP_011278757.1	hypothetical protein	-
B6A19_RS09585	1765470..1765889	+	420	WP_011278758.1	PIN domain-containing protein	-
B6A19_RS09590	1766098..1766493	-	396	WP_011278759.1	PIN domain-containing protein	Toxin
B6A19_RS09595	1766477..1766704	-	228	WP_011278760.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
B6A19_RS09600	1766804..1767247	-	444	WP_011278761.1	MarR family transcriptional regulator	-
B6A19_RS09605	1767234..1768937	-	1704	WP_011278762.1	MFS transporter	-
B6A19_RS09610	1769514..1770011	+	498	WP_011278763.1	hypothetical protein	-
B6A19_RS09615	1770032..1770703	+	672	WP_015385737.1	hypothetical protein	-
B6A19_RS11960	1770709..1771476	+	768	WP_011278765.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (3-44)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15289.79 Da
• Isoelectric Point: 5.7030

>T74406 WP_011278759.1 NZ_CP020364:c1766493-1766098 [Sulfolobus acidocaldarius]
MKILVDTNVLIYDLVENSKFHKEAEDILDRAETWVIPSVVVHELVWFLRANNLERMDYVSAYVESPKAEIVCEDFDVLKN
AMEIILREKISLSRYNDPVILSHAILRKLPLSTFDRRLSNLAKRYGIDIVK

Nucleotide

• Length: 396 bp

>T74406 NZ_CP020364:c1766493-1766098 [Sulfolobus acidocaldarius]
ATGAAAATTTTAGTTGATACTAACGTACTAATCTATGACCTCGTGGAGAACTCAAAGTTTCACAAGGAAGCTGAGGATAT
ATTGGACAGAGCAGAAACTTGGGTCATACCTTCTGTAGTCGTTCATGAGCTAGTATGGTTCTTGAGGGCGAATAACCTGG
AGAGAATGGACTACGTATCAGCATATGTGGAAAGCCCCAAGGCTGAAATAGTGTGCGAGGACTTTGATGTTTTAAAGAAC
GCAATGGAAATAATACTGAGGGAAAAGATATCTCTTTCTAGGTATAATGACCCAGTAATACTCTCACACGCGATTCTCAG
GAAGTTACCACTTTCGACGTTTGATAGGAGACTCTCCAACTTGGCAAAGAGGTACGGAATAGACATAGTTAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8808.27 Da
• Isoelectric Point: 8.4634

>AT74406 WP_011278760.1 NZ_CP020364:c1766704-1766477 [Sulfolobus acidocaldarius]
VEKVKVTRNYQVTIPSSVRNVLGIKEGDILEVYVENDKIVMKKVESKRPRIKIEKLMTIEYIEESIERGMHENFS

Nucleotide

• Length: 228 bp

>AT74406 NZ_CP020364:c1766704-1766477 [Sulfolobus acidocaldarius]
GTGGAGAAGGTAAAAGTTACTAGGAACTACCAGGTCACGATACCTTCATCTGTGAGGAACGTCCTAGGAATTAAGGAGGG
TGATATTTTGGAGGTGTACGTAGAGAATGATAAAATAGTGATGAAGAAGGTAGAGTCTAAGAGACCTAGGATAAAGATTG
AAAAACTTATGACCATAGAATATATAGAGGAAAGTATAGAGAGAGGCATGCATGAAAATTTTAGTTGA

Structures

Toxin

• AlphaFold DB: M1ITB5

Antitoxin

• AlphaFold DB: M1I7B9