Detailed information of TA system TA074399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 2080072..2081059
• Replicon: chromosome
• Accession: NZ_CP020362
• Organism: Sulfolobus acidocaldarius strain Y14 16-22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1IU00
• Locus tag: B6A17_RS11140
• Protein ID: WP_011278971.1
• Coordinates: 2080072..2080689 (-)
• Length: 206 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I835
• Locus tag: B6A17_RS11145
• Protein ID: WP_011278972.1
• Coordinates: 2080715..2081059 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A17_RS11125	2075675..2076277	+	603	WP_011278968.1	hypothetical protein	-
B6A17_RS11130	2076329..2077720	-	1392	WP_011278969.1	APC family permease	-
B6A17_RS11135	2077871..2079865	+	1995	WP_011278970.1	primary-amine oxidase	-
B6A17_RS11140	2080072..2080689	-	618	WP_011278971.1	helix-turn-helix domain-containing protein	Toxin
B6A17_RS11145	2080715..2081059	-	345	WP_011278972.1	DUF488 domain-containing protein	Antitoxin
B6A17_RS11150	2081365..2082153	+	789	WP_011278973.1	aldose 1-epimerase	-
B6A17_RS11155	2082451..2083479	+	1029	WP_088899929.1	NAD-binding protein	-
B6A17_RS11160	2084067..2084696	-	630	WP_011278975.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (146-196)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 206 a.a.
• Molecular weight: 23779.04 Da
• Isoelectric Point: 9.9689

>T74399 WP_011278971.1 NZ_CP020362:c2080689-2080072 [Sulfolobus acidocaldarius]
MVFASKRPIEVTLLVDKHPCEVLDIFRKYEIKAQITNVKLRDQVTDHIAFLKINDDILKELKRRSLKTLRINENTIWIRT
NGCGVCKLLYHSDLIVEKVKVLSKATVMYKLLLPNLSALKQFLEELNSIRVEATVANVSEIDESELTDRQLEILRLAYKS
GYFDVDRKISMKELANKLGIKASTLEEILRRALKKAVKYYLDRKS

Nucleotide

• Length: 618 bp

>T74399 NZ_CP020362:c2080689-2080072 [Sulfolobus acidocaldarius]
ATGGTCTTTGCCTCAAAGAGACCCATTGAAGTTACACTCCTAGTGGATAAACACCCATGCGAAGTCTTAGACATATTTAG
AAAATATGAAATTAAGGCTCAGATAACTAATGTTAAGCTAAGGGATCAGGTTACTGACCATATTGCATTCCTTAAGATAA
ACGATGATATACTCAAGGAATTAAAGAGAAGGTCTCTTAAAACTTTAAGGATAAATGAAAATACCATTTGGATAAGGACA
AACGGTTGCGGCGTTTGTAAACTACTCTATCACTCTGACCTAATTGTGGAAAAGGTAAAGGTGTTAAGTAAAGCTACTGT
TATGTATAAACTTCTATTACCAAATCTTTCTGCATTGAAACAGTTTTTAGAAGAACTGAACAGCATAAGAGTAGAGGCTA
CAGTTGCCAATGTATCAGAAATTGACGAGAGCGAGTTAACAGATAGACAATTGGAAATCCTGAGATTGGCTTACAAATCA
GGCTATTTTGATGTCGATAGGAAAATCTCGATGAAGGAATTAGCCAATAAATTGGGGATAAAGGCATCTACGCTAGAGGA
GATACTGAGGAGGGCTCTAAAAAAGGCTGTAAAATATTATTTGGACAGAAAGAGCTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13706.92 Da
• Isoelectric Point: 9.2564

>AT74399 WP_011278972.1 NZ_CP020362:c2081059-2080715 [Sulfolobus acidocaldarius]
MIKVKRVYDAPESDDGVRILIDRLWPRGVKKDLVDIWMKDIAPSDELRKWFNHEPEKWEEFKHKYMEELRSNPKVKVLIE
VIRRSENVTFLYATKSPYNNAVVLKEYIESLLTK

Nucleotide

• Length: 345 bp

>AT74399 NZ_CP020362:c2081059-2080715 [Sulfolobus acidocaldarius]
ATGATTAAGGTCAAGCGAGTTTATGACGCACCTGAATCTGATGATGGGGTCAGAATATTGATTGACCGATTATGGCCTAG
AGGAGTAAAGAAAGATCTAGTGGATATTTGGATGAAAGATATTGCTCCATCAGATGAGTTAAGGAAATGGTTTAATCATG
AACCTGAAAAGTGGGAAGAGTTTAAGCACAAGTATATGGAGGAGCTTAGAAGTAACCCTAAGGTCAAAGTCTTAATCGAG
GTAATAAGGAGAAGCGAAAATGTTACATTCCTATATGCCACTAAATCGCCTTACAATAATGCGGTAGTTTTAAAGGAGTA
TATTGAAAGTTTGTTAACAAAATAA

Structures

Toxin

• AlphaFold DB: M1IU00

Antitoxin

• AlphaFold DB: M1I835