Detailed information of TA system TA074398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 2061081..2062063
• Replicon: chromosome
• Accession: NZ_CP020362
• Organism: Sulfolobus acidocaldarius strain Y14 16-22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1IXW8
• Locus tag: B6A17_RS11065
• Protein ID: WP_011278959.1
• Coordinates: 2061443..2062063 (+)
• Length: 207 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I813
• Locus tag: B6A17_RS11060
• Protein ID: WP_011278958.1
• Coordinates: 2061081..2061431 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A17_RS11040	2056485..2058419	-	1935	WP_011278954.1	DUF2079 domain-containing protein	-
B6A17_RS11045	2058628..2059332	+	705	WP_011278955.1	zinc ribbon domain-containing protein	-
B6A17_RS11050	2059416..2060060	-	645	WP_011278956.1	2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase	-
B6A17_RS11055	2060107..2060802	-	696	WP_011278957.1	glycerophosphodiester phosphodiesterase	-
B6A17_RS11060	2061081..2061431	+	351	WP_011278958.1	DUF488 family protein	Antitoxin
B6A17_RS11065	2061443..2062063	+	621	WP_011278959.1	helix-turn-helix domain-containing protein	Toxin
B6A17_RS11070	2062168..2063574	-	1407	WP_015385784.1	amidase	-
B6A17_RS11075	2063778..2064227	+	450	WP_230937910.1	hypothetical protein	-
B6A17_RS11080	2064317..2065963	-	1647	WP_011278962.1	thermopsin family protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (147-197)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 207 a.a.
• Molecular weight: 23490.89 Da
• Isoelectric Point: 9.6857

>T74398 WP_011278959.1 NZ_CP020362:2061443-2062063 [Sulfolobus acidocaldarius]
MGAGDVKKPINVTLILQNHPCLVMKLFEEMNVKAEINNVKMRESVTDHIATLKLTEKLLKELKERRSKTLRISENSVWIR
TEGCQVCKILYVSDAVVEKVKVVGSDAVMYKLIVPNLLSLKSLIDELNKIGVKAMVGSISELDEEQLTERQLEILKLSYK
MGFFDVDRRITMTELAEKLGIKAPTLEEILRRALRKAVKYYLDKKG

Nucleotide

• Length: 621 bp

>T74398 NZ_CP020362:2061443-2062063 [Sulfolobus acidocaldarius]
ATGGGTGCTGGTGATGTAAAGAAACCTATAAATGTTACACTTATTCTACAGAATCACCCCTGCTTAGTTATGAAATTATT
TGAAGAGATGAATGTAAAGGCGGAAATTAACAATGTGAAGATGAGGGAAAGTGTTACTGACCACATTGCAACCTTAAAGT
TAACTGAAAAGTTGCTTAAGGAGTTGAAAGAAAGAAGGTCAAAAACCTTGAGGATAAGTGAAAATAGCGTCTGGATCAGG
ACTGAAGGTTGCCAGGTATGTAAAATCCTTTATGTAAGTGACGCTGTAGTTGAGAAAGTGAAAGTTGTAGGAAGTGATGC
AGTTATGTATAAACTAATTGTTCCAAATCTACTCTCTCTGAAGAGTCTTATAGATGAGCTCAACAAGATAGGTGTAAAGG
CTATGGTAGGTAGCATATCTGAGCTAGATGAAGAGCAACTGACAGAAAGGCAATTGGAGATATTGAAATTATCATATAAG
ATGGGTTTCTTTGATGTAGACAGAAGAATAACCATGACGGAATTAGCTGAAAAACTTGGGATCAAGGCTCCTACTTTGGA
AGAGATACTGAGAAGGGCTCTACGAAAGGCAGTTAAGTATTATCTAGATAAAAAAGGATAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 13918.19 Da
• Isoelectric Point: 8.2649

>AT74398 WP_011278958.1 NZ_CP020362:2061081-2061431 [Sulfolobus acidocaldarius]
MIKIKNVYDKPEINDGIRILVERTWPASVTRGSIDMWLRDLAPSEELITWYNYEPQKWEEFKRRYLEELRYNPKVKPLLM
IVKMTKIVTFLYSGDPTYNNAVVLKEYIESLINKES

Nucleotide

• Length: 351 bp

>AT74398 NZ_CP020362:2061081-2061431 [Sulfolobus acidocaldarius]
ATGATAAAAATAAAAAACGTTTATGACAAACCAGAGATTAACGACGGGATTAGAATATTGGTCGAGAGGACATGGCCAGC
CTCTGTAACTAGAGGCTCTATCGATATGTGGCTTAGGGATCTTGCCCCTTCTGAAGAATTAATAACATGGTATAATTATG
AACCGCAAAAATGGGAGGAATTTAAGAGAAGATATCTAGAAGAGTTGAGGTACAATCCAAAAGTTAAACCTTTATTGATG
ATAGTTAAGATGACTAAGATCGTAACATTTCTATACTCAGGAGACCCCACATACAATAACGCAGTTGTGCTCAAAGAATA
CATAGAAAGTTTAATAAATAAGGAAAGTTAA

Structures

Toxin

• AlphaFold DB: M1IXW8

Antitoxin

• AlphaFold DB: M1I813