Detailed information of TA system TA074392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1807543..1808046
• Replicon: chromosome
• Accession: NZ_CP020361
• Organism: Sulfolobus acidocaldarius strain Y14 20-20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B6A16_RS12280
• Protein ID: WP_162465564.1
• Coordinates: 1807891..1808046 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: B6A16_RS09820
• Protein ID: WP_011278775.1
• Coordinates: 1807543..1807785 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A16_RS09800	1803055..1804542	+	1488	WP_230949672.1	AMP-binding protein	-
B6A16_RS09805	1804529..1805647	+	1119	WP_011278772.1	arabinonate dehydratase	-
B6A16_RS09810	1805649..1806809	+	1161	WP_088922591.1	thiolase family protein	-
B6A16_RS09815	1806802..1807146	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
B6A16_RS09820	1807543..1807785	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
B6A16_RS12280	1807891..1808046	+	156	WP_162465564.1	hypothetical protein	Toxin
B6A16_RS09825	1808505..1809830	+	1326	WP_015385888.1	APC family permease	-
B6A16_RS09830	1809989..1812235	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T74392 WP_162465564.1 NZ_CP020361:1807891-1808046 [Sulfolobus acidocaldarius]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T74392 NZ_CP020361:1807891-1808046 [Sulfolobus acidocaldarius]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT74392 WP_011278775.1 NZ_CP020361:1807543-1807785 [Sulfolobus acidocaldarius]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT74392 NZ_CP020361:1807543-1807785 [Sulfolobus acidocaldarius]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0