Detailed information of TA system TA074387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1708799..1709302
• Replicon: chromosome
• Accession: NZ_CP020360
• Organism: Sulfolobus acidocaldarius strain Y14 18-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: B6A18_RS11930
• Protein ID: WP_162465564.1
• Coordinates: 1709147..1709302 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: B6A18_RS09485
• Protein ID: WP_011278775.1
• Coordinates: 1708799..1709041 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6A18_RS09465	1704311..1705798	+	1488	WP_230949672.1	AMP-binding protein	-
B6A18_RS09470	1705785..1706903	+	1119	WP_011278772.1	arabinonate dehydratase	-
B6A18_RS09475	1706905..1708065	+	1161	WP_011278773.1	thiolase family protein	-
B6A18_RS09480	1708058..1708402	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
B6A18_RS09485	1708799..1709041	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
B6A18_RS11930	1709147..1709302	+	156	WP_162465564.1	hypothetical protein	Toxin
B6A18_RS09490	1709761..1711086	+	1326	WP_015385888.1	APC family permease	-
B6A18_RS09495	1711245..1713491	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T74387 WP_162465564.1 NZ_CP020360:1709147-1709302 [Sulfolobus acidocaldarius]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T74387 NZ_CP020360:1709147-1709302 [Sulfolobus acidocaldarius]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT74387 WP_011278775.1 NZ_CP020360:1708799-1709041 [Sulfolobus acidocaldarius]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT74387 NZ_CP020360:1708799-1709041 [Sulfolobus acidocaldarius]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0