Detailed information of TA system TA074384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4833534..4834353
• Replicon: chromosome
• Accession: NZ_CP020358
• Organism: Klebsiella oxytoca strain AR_0147

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: AM394_RS23510
• Protein ID: WP_004110819.1
• Coordinates: 4833534..4833791 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AM394_RS23515
• Protein ID: WP_080528515.1
• Coordinates: 4833802..4834353 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM394_RS23495	4829210..4829986	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
AM394_RS23500	4830125..4831600	-	1476	WP_080528514.1	fructuronate reductase	-
AM394_RS23505	4831674..4832858	-	1185	WP_047724369.1	mannonate dehydratase	-
AM394_RS23510	4833534..4833791	+	258	WP_004110819.1	YjhX family toxin	Toxin
AM394_RS23515	4833802..4834353	+	552	WP_080528515.1	N-acetyltransferase	Antitoxin
AM394_RS23520	4834371..4835999	+	1629	WP_080528516.1	SAM-dependent methyltransferase	-
AM394_RS23525	4836124..4837464	-	1341	WP_057173103.1	carbohydrate porin	-
AM394_RS23530	4837586..4838983	-	1398	WP_014228060.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T74384 WP_004110819.1 NZ_CP020358:4833534-4833791 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T74384 NZ_CP020358:4833534-4833791 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20018.92 Da
• Isoelectric Point: 6.7596

>AT74384 WP_080528515.1 NZ_CP020358:4833802-4834353 [Klebsiella oxytoca]
MTNYSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYRGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT74384 NZ_CP020358:4833802-4834353 [Klebsiella oxytoca]
ATGACAAACTACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCGGGGCGTGGGCGTTGGCGGAGGGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGATGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2