Detailed information of TA system TA074380

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2719054..2719711
• Replicon: chromosome
• Accession: NZ_CP020358
• Organism: Klebsiella oxytoca strain AR_0147

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: AM394_RS13345
• Protein ID: WP_080528376.1
• Coordinates: 2719054..2719464 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: AM394_RS13350
• Protein ID: WP_004124953.1
• Coordinates: 2719445..2719711 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM394_RS13325	2715031..2716764	-	1734	WP_032751182.1	single-stranded-DNA-specific exonuclease RecJ	-
AM394_RS13330	2716770..2717483	-	714	WP_004854054.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AM394_RS13335	2717506..2718402	-	897	WP_004105555.1	site-specific tyrosine recombinase XerD	-
AM394_RS13340	2718524..2719045	+	522	WP_014226792.1	flavodoxin FldB	-
AM394_RS13345	2719054..2719464	-	411	WP_080528376.1	protein YgfX	Toxin
AM394_RS13350	2719445..2719711	-	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
AM394_RS13355	2719956..2720939	+	984	WP_014226793.1	tRNA-modifying protein YgfZ	-
AM394_RS13360	2721133..2723931	+	2799	WP_014226794.1	transcriptional regulator DagR	-
AM394_RS13365	2724052..2724477	+	426	WP_004854067.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16139.03 Da
• Isoelectric Point: 10.9455

>T74380 WP_080528376.1 NZ_CP020358:c2719464-2719054 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGMVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Nucleotide

• Length: 411 bp

>T74380 NZ_CP020358:c2719464-2719054 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCATGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCT
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT74380 WP_004124953.1 NZ_CP020358:c2719711-2719445 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT74380 NZ_CP020358:c2719711-2719445 [Klebsiella oxytoca]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9