Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 523078..523721 Replicon chromosome
Accession NZ_CP020358
Organism Klebsiella oxytoca strain AR_0147

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag AM394_RS02555 Protein ID WP_040225651.1
Coordinates 523078..523494 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag AM394_RS02560 Protein ID WP_001261276.1
Coordinates 523491..523721 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM394_RS31515 518964..520616 + 1653 WP_115657786.1 L-tyrosine/L-tryptophan isonitrile synthase family protein -
AM394_RS02535 520682..521917 + 1236 WP_048292257.1 MFS transporter -
AM394_RS02540 522017..522410 - 394 Protein_483 CAAX protease -
AM394_RS02545 522481..522735 - 255 Protein_484 hypothetical protein -
AM394_RS02550 522799..523044 - 246 WP_040225648.1 hypothetical protein -
AM394_RS02555 523078..523494 - 417 WP_040225651.1 type II toxin-antitoxin system VapC family toxin Toxin
AM394_RS02560 523491..523721 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AM394_RS02570 524258..524572 + 315 WP_001302628.1 hypothetical protein -
AM394_RS02575 524625..525410 + 786 WP_048292255.1 hypothetical protein -
AM394_RS02580 525486..525863 + 378 WP_004118218.1 IS66 family insertion sequence hypothetical protein -
AM394_RS02585 525860..526207 + 348 WP_048292253.1 IS66 family insertion sequence element accessory protein TnpB -
AM394_RS02590 526257..527795 + 1539 WP_048292251.1 IS66 family transposase -
AM394_RS02595 528249..528653 - 405 WP_048292250.1 DUF2251 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15089.57 Da        Isoelectric Point: 8.5464

>T74371 WP_040225651.1 NZ_CP020358:c523494-523078 [Klebsiella oxytoca]
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T74371 NZ_CP020358:c523494-523078 [Klebsiella oxytoca]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAATCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCATCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCGGGCCTGGTGCTTG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT74371 WP_001261276.1 NZ_CP020358:c523721-523491 [Klebsiella oxytoca]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT74371 NZ_CP020358:c523721-523491 [Klebsiella oxytoca]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References