Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 523078..523721 | Replicon | chromosome |
Accession | NZ_CP020358 | ||
Organism | Klebsiella oxytoca strain AR_0147 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | - |
Locus tag | AM394_RS02555 | Protein ID | WP_040225651.1 |
Coordinates | 523078..523494 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q84A07 |
Locus tag | AM394_RS02560 | Protein ID | WP_001261276.1 |
Coordinates | 523491..523721 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM394_RS31515 | 518964..520616 | + | 1653 | WP_115657786.1 | L-tyrosine/L-tryptophan isonitrile synthase family protein | - |
AM394_RS02535 | 520682..521917 | + | 1236 | WP_048292257.1 | MFS transporter | - |
AM394_RS02540 | 522017..522410 | - | 394 | Protein_483 | CAAX protease | - |
AM394_RS02545 | 522481..522735 | - | 255 | Protein_484 | hypothetical protein | - |
AM394_RS02550 | 522799..523044 | - | 246 | WP_040225648.1 | hypothetical protein | - |
AM394_RS02555 | 523078..523494 | - | 417 | WP_040225651.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
AM394_RS02560 | 523491..523721 | - | 231 | WP_001261276.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
AM394_RS02570 | 524258..524572 | + | 315 | WP_001302628.1 | hypothetical protein | - |
AM394_RS02575 | 524625..525410 | + | 786 | WP_048292255.1 | hypothetical protein | - |
AM394_RS02580 | 525486..525863 | + | 378 | WP_004118218.1 | IS66 family insertion sequence hypothetical protein | - |
AM394_RS02585 | 525860..526207 | + | 348 | WP_048292253.1 | IS66 family insertion sequence element accessory protein TnpB | - |
AM394_RS02590 | 526257..527795 | + | 1539 | WP_048292251.1 | IS66 family transposase | - |
AM394_RS02595 | 528249..528653 | - | 405 | WP_048292250.1 | DUF2251 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15089.57 Da Isoelectric Point: 8.5464
>T74371 WP_040225651.1 NZ_CP020358:c523494-523078 [Klebsiella oxytoca]
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T74371 NZ_CP020358:c523494-523078 [Klebsiella oxytoca]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAATCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCATCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCGGGCCTGGTGCTTG
AAGACTGGGTGAAATAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAATCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCATCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCGGGCCTGGTGCTTG
AAGACTGGGTGAAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT74371 WP_001261276.1 NZ_CP020358:c523721-523491 [Klebsiella oxytoca]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT74371 NZ_CP020358:c523721-523491 [Klebsiella oxytoca]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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