Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 839244..839721 Replicon chromosome
Accession NZ_CP020354
Organism Staphylococcus aureus strain FORC59

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FORC59_RS04205 Protein ID WP_000052076.1
Coordinates 839244..839432 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FORC59_RS04210 Protein ID WP_001059690.1
Coordinates 839461..839721 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC59_RS04175 835279..835749 + 471 WP_000824472.1 hypothetical protein -
FORC59_RS04180 836090..836776 + 687 WP_001566557.1 thermonuclease family protein -
FORC59_RS04185 837133..837333 + 201 WP_001059082.1 cold-shock protein -
FORC59_RS04190 837828..838053 - 226 Protein_768 hypothetical protein -
FORC59_RS04195 838115..838399 - 285 WP_001004394.1 hypothetical protein -
FORC59_RS04200 838487..839056 - 570 WP_001106652.1 hypothetical protein -
FORC59_RS04205 839244..839432 - 189 WP_000052076.1 hypothetical protein Toxin
FORC59_RS04210 839461..839721 - 261 WP_001059690.1 hypothetical protein Antitoxin
FORC59_RS04215 840062..840265 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FORC59_RS04220 840262..840498 - 237 WP_000368687.1 hypothetical protein -
FORC59_RS04225 840723..841304 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
FORC59_RS04230 841377..841994 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FORC59_RS04235 842149..842643 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FORC59_RS04240 843042..843464 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FORC59_RS04245 843612..844328 + 717 WP_000150019.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T74356 WP_000052076.1 NZ_CP020354:c839432-839244 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T74356 NZ_CP020354:c839432-839244 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT74356 WP_001059690.1 NZ_CP020354:c839721-839461 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT74356 NZ_CP020354:c839721-839461 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References