74352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 5659676..5660315 Replicon chromosome
Accession NZ_CP020351
Organism Pseudomonas amygdali pv. lachrymans strain NM002

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z6Y3C5
Locus tag B5U27_RS26930 Protein ID WP_005781617.1
Coordinates 5659676..5659858 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Q0DRU8
Locus tag B5U27_RS26935 Protein ID WP_016981256.1
Coordinates 5659890..5660315 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5U27_RS26900 5655037..5655630 + 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -
B5U27_RS26905 5655630..5656268 + 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
B5U27_RS26910 5656273..5656533 + 261 WP_002551456.1 DUF2164 domain-containing protein -
B5U27_RS26915 5656641..5657378 + 738 WP_002551457.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
B5U27_RS26920 5657398..5658168 + 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
B5U27_RS26925 5658354..5659109 + 756 WP_004663214.1 ABC transporter substrate-binding protein -
B5U27_RS29545 5659114..5659354 - 241 Protein_5081 serine protease -
B5U27_RS26930 5659676..5659858 + 183 WP_005781617.1 type II toxin-antitoxin system HicA family toxin Toxin
B5U27_RS26935 5659890..5660315 + 426 WP_016981256.1 transcriptional regulator Antitoxin
B5U27_RS26940 5660370..5661152 - 783 WP_005745049.1 divergent polysaccharide deacetylase family protein -
B5U27_RS26945 5661156..5662499 - 1344 WP_005745050.1 S41 family peptidase -
B5U27_RS26950 5662533..5663855 - 1323 WP_029240926.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6877.97 Da        Isoelectric Point: 10.6211

>T74352 WP_005781617.1 NZ_CP020351:5659676-5659858 [Pseudomonas amygdali pv. lachrymans]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T74352 NZ_CP020351:5659676-5659858 [Pseudomonas amygdali pv. lachrymans]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15783.24 Da        Isoelectric Point: 5.2548

>AT74352 WP_016981256.1 NZ_CP020351:5659890-5660315 [Pseudomonas amygdali pv. lachrymans]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT74352 NZ_CP020351:5659890-5660315 [Pseudomonas amygdali pv. lachrymans]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Y3C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0DRU8

References