74351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 5254416..5255011 Replicon chromosome
Accession NZ_CP020351
Organism Pseudomonas amygdali pv. lachrymans strain NM002

Toxin (Protein)


Gene name relE Uniprot ID A0A3M3ZKH5
Locus tag B5U27_RS24825 Protein ID WP_005746690.1
Coordinates 5254416..5254718 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0P9S822
Locus tag B5U27_RS24830 Protein ID WP_005746689.1
Coordinates 5254721..5255011 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5U27_RS24805 5249749..5251089 - 1341 WP_080164792.1 precorrin-3B synthase -
B5U27_RS24810 5251215..5252417 + 1203 WP_005746695.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
B5U27_RS24815 5252417..5253529 + 1113 WP_005746694.1 cobalt-precorrin-5B (C(1))-methyltransferase -
B5U27_RS24820 5253526..5254266 + 741 WP_005746691.1 cobalt-precorrin-6A reductase -
B5U27_RS24825 5254416..5254718 + 303 WP_005746690.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5U27_RS24830 5254721..5255011 + 291 WP_005746689.1 putative addiction module antidote protein Antitoxin
B5U27_RS24835 5255082..5255543 + 462 WP_005746687.1 copper chaperone PCu(A)C -
B5U27_RS24840 5255557..5255991 + 435 WP_005746686.1 DUF2946 domain-containing protein -
B5U27_RS24845 5256076..5257449 + 1374 WP_005746685.1 PepSY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-86)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11477.21 Da        Isoelectric Point: 10.6008

>T74351 WP_005746690.1 NZ_CP020351:5254416-5254718 [Pseudomonas amygdali pv. lachrymans]
MNRFEQTPAFAEWLRSLKDSIGRARILARIRAAELGNFGDCDALGQGVRELRIHHGPGYRVYFARRTGVVYLLLIAGDKS
SQKRDIKFARQLARELCERE

Download         Length: 303 bp

>T74351 NZ_CP020351:5254416-5254718 [Pseudomonas amygdali pv. lachrymans]
ATGAATCGCTTTGAACAGACGCCCGCTTTTGCGGAGTGGTTAAGGTCGTTGAAGGACTCCATTGGCAGAGCTCGAATTCT
GGCTCGAATAAGAGCAGCAGAGCTCGGTAACTTCGGGGACTGCGATGCTTTAGGTCAAGGCGTCAGAGAGCTACGAATAC
ACCATGGACCAGGTTATCGGGTGTATTTTGCCCGACGCACGGGTGTGGTTTACCTGCTCTTGATCGCTGGTGACAAATCG
TCTCAAAAGCGCGACATAAAATTTGCCAGACAGCTGGCGAGAGAGCTCTGTGAGAGGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10500.87 Da        Isoelectric Point: 4.5720

>AT74351 WP_005746689.1 NZ_CP020351:5254721-5255011 [Pseudomonas amygdali pv. lachrymans]
MNNETTPFDTVDYLKTPEDMANYLDACLEEDSGDGLLVRAALNDIARAYGMTQIARDTGLGRESLYKALGANGNPEFTTI
MKVVRAMGIKLHASTR

Download         Length: 291 bp

>AT74351 NZ_CP020351:5254721-5255011 [Pseudomonas amygdali pv. lachrymans]
ATGAACAACGAGACGACACCGTTCGATACCGTCGACTATTTGAAGACACCTGAAGATATGGCCAATTATCTGGATGCGTG
TCTTGAAGAGGATTCAGGAGACGGGCTGCTCGTAAGGGCCGCGCTGAACGACATAGCAAGGGCTTATGGCATGACACAAA
TCGCACGTGATACAGGTCTTGGTCGTGAGAGCCTCTACAAAGCGCTGGGTGCAAACGGTAATCCAGAGTTCACGACCATC
ATGAAAGTCGTGAGGGCGATGGGGATCAAACTACACGCAAGTACGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3ZKH5

Antitoxin

Source ID Structure
AlphaFold DB A0A0P9S822

References