Detailed information of TA system TA074350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 3930153..3930666
• Replicon: chromosome
• Accession: NZ_CP020351
• Organism: Pseudomonas amygdali pv. lachrymans strain NM002

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B5U27_RS18595
• Protein ID: WP_004658391.1
• Coordinates: 3930382..3930666 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0N8T2X1
• Locus tag: B5U27_RS18590
• Protein ID: WP_029241049.1
• Coordinates: 3930153..3930392 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5U27_RS18570	3926262..3927047	+	786	WP_002552796.1	membrane protein	-
B5U27_RS18575	3927226..3928134	-	909	WP_005744311.1	DUF808 domain-containing protein	-
B5U27_RS18580	3928284..3928790	-	507	WP_004658394.1	Lrp/AsnC family transcriptional regulator	-
B5U27_RS18585	3928977..3929993	+	1017	WP_002552793.1	1-aminocyclopropane-1-carboxylate deaminase	-
B5U27_RS18590	3930153..3930392	+	240	WP_029241049.1	CopG family ribbon-helix-helix protein	Antitoxin
B5U27_RS18595	3930382..3930666	+	285	WP_004658391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B5U27_RS18600	3930703..3931557	-	855	WP_004658390.1	LysR family transcriptional regulator	-
B5U27_RS18605	3931632..3932564	+	933	WP_039847441.1	DMT family transporter	-
B5U27_RS18610	3932595..3934523	-	1929	WP_010198401.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10647.31 Da
• Isoelectric Point: 10.4249

>T74350 WP_004658391.1 NZ_CP020351:3930382-3930666 [Pseudomonas amygdali pv. lachrymans]
MQVEWLKTALKNLDEEAAYIAQDNPAAAAAFVKAIQSSVTQLASFPAMGREGRIAGTREWPLPDLPYLIPYRIRSGRLQV
LRIFHTRRQSPPVW

Nucleotide

• Length: 285 bp

>T74350 NZ_CP020351:3930382-3930666 [Pseudomonas amygdali pv. lachrymans]
ATGCAGGTTGAGTGGCTTAAAACGGCGCTAAAGAATCTGGATGAGGAGGCAGCGTATATCGCACAGGACAATCCAGCTGC
TGCCGCAGCTTTCGTGAAAGCAATTCAATCAAGCGTGACGCAGCTCGCGAGCTTTCCCGCCATGGGCCGGGAAGGACGGA
TTGCCGGAACCAGAGAATGGCCTCTGCCAGACCTGCCTTACCTGATTCCATATCGCATCCGTAGCGGCCGGCTACAGGTT
CTAAGGATTTTCCACACCAGAAGACAATCGCCCCCCGTGTGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8715.80 Da
• Isoelectric Point: 4.4354

>AT74350 WP_029241049.1 NZ_CP020351:3930153-3930392 [Pseudomonas amygdali pv. lachrymans]
MSTMSLRLPDEMADTLAHLAKATGRSKSFLALDALREYLTREAWQIAEIQRAIEEADAGEFANTEDVKAVMDKWSGNAG

Nucleotide

• Length: 240 bp

>AT74350 NZ_CP020351:3930153-3930392 [Pseudomonas amygdali pv. lachrymans]
ATGTCCACAATGTCTCTACGTCTGCCGGACGAAATGGCGGATACCCTTGCACACCTTGCAAAGGCGACCGGGCGCAGCAA
GTCATTTTTGGCCCTCGACGCGCTCCGCGAATACCTGACTCGCGAGGCATGGCAGATTGCCGAAATTCAGCGCGCGATTG
AAGAAGCCGACGCTGGCGAGTTCGCCAATACAGAGGACGTAAAAGCTGTCATGGACAAATGGTCTGGCAATGCAGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0N8T2X1